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This paper investigates the role of flood risk experts in supporting homeowners to implement property-level flood risk adaption (PLFRA). Homeowners can reduce their flood risks by implementing PLFRA. However, oftentimes they need advice on what sort of and how to implement PLFRA. This means that tailored experts advice is necessary to inform homeowners on such measures. But experience shows that mere information is often insufficient to motivate homeowners to realise measures. This contributi...
Dressing electronic quantumstates with virtual photons creates exotic effects ranging from vacuum-field modified transport to polaritonic chemistry, and squeezing or entanglement of modes. The established paradigm of cavity quantum electrodynamics maximizes the light-matter coupling strength ΩR=ωc, defined as the ratio of the vacuumRabi frequency and the frequency of light, by resonant interactions. Yet, the finite oscillator strength of a single electronic excitation sets a natural limit to ...
Tissue homeostasis and disease states rely on the formation of new blood vessels through angiogenic sprouting, which is tightly regulated by the properties of the surrounding extracellular matrix. While physical cues, such as matrix stiffness or degradability, have evolved as major regulators of cell function in tissue microenvironments, it remains unknown whether and how physical cues regulate endothelial cell migration during angiogenesis. To investigate this, a biomimetic model of angiogen...
Simulation is a crucial tool for the evaluation and comparison of statistical methods. How to design fair and neutral simulation studies is therefore of great interest for both researchers developing new methods and practitioners confronted with the choice of the most suitable method. The term simulation usually refers to parametric simulation, that is, computer experiments using artificial data made up of pseudo-random numbers. Plasmode simulation, that is, computer experiments using the com...
Contaminated air quality, in lieu of massive industrial pollution, is severely attributing to health anomalies in the proximity of industrial units. Cardiovascular Disease (CAD) is rising around industrial units in the planned capital city of Pakistan, Pakistan. To study self-reported CAD in the proximity of Industrial Estate Islamabad (IEI) by equating two distinct study groups as ‘Band-I’: the residence 0–650 meters and ‘Band-II’ 650–1300 meters radius around the perimeter of IEI. The perim...
I develop a challenge to reductive views of knowing that ϕ that appeal to what I call a gradable property. Such appeal allows for properties that are intrinsically very similar to the property of knowing that ϕ, but differ significantly in their normative significance. This violates the independently plausible claim Pautz (2017) labels the ‘small difference principle.’
We propose a new full discretization of the Biot’s equations in poroelasticity. The construction is driven by the inf-sup theory, which we recently developed. It builds upon the four-field formulation of the equations obtained by introducing the total pressure and the total fluid content. We discretize in space with Lagrange finite elements and in time with backward Euler. We establish inf-sup stability and quasi-optimality of the proposed discretization, with robust constants with respect t...
The objective of this series of tests is to characterize the alkali and water resistance of two non-vulcanized formulations based on co-polymerizing styrene–butadiene rubbers (SBR1 and SBR2). The relative merits of the two polymer systems as impregnating agents for alkali-resistant glass reinforcement in cementitious binders are assessed. For this purpose, polymer films were synthesized and then chemically conditioned for up to half a year at temperatures of 23 °C and 50 °C in sodium hydroxid...
Die Ser/Thr-Kinase Akt (Proteinkinase B) ist ein zentraler Regulator im PI3K/Akt/mTOR-Signalnetzwerk, der am häufigsten aktivierten Signalkaskade bei malignen humanen Erkrankungen. Die durch Akt vermittelte Signaltransduktion stellt einen wesentlichen Bestandteil grundlegender physiologischer Prozesse dar, zu denen Zellproliferation, Überleben, Stoffwechsel und Proteinbiosynthese zählen. Veränderungen in den Akt-regulierenden Proteinen wie PI3K und PTEN können zu einer Akt-Hyperaktivität führ...
The transition from an RNA-based world to DNA as the primary genetic material is a pivotal topic in origin-of-life research. This study aims to prototype a hybrid genome system combining DNA and RNA, capable of self-replication and evolution, initially in vitro and potentially in vivo. Using Qß replicase, segmented RNA genomes were synthesized, incorporating the Phi29 phage pRNA for self-assembly into nanorings. The replication efficacy of these replicons was evaluated both independently...
Different mammalian species progress through similar stages during embryonic development and adult life but the pace of these transitions is species-specific. While classically, developmental timing was viewed merely as a consequence of varying body sizes between species, the use of pluripotent stem cells (PSCs) has shown that species-specific developmental timing is maintained during in vitro differentiation. Since then, uncovering cell-intrinsic mechanisms that regulate the timescales of de...
Avapritinib is the only potent and selective inhibitor approved for the treatment of D842V-mutant gastrointestinal stromal tumors (GIST), the most common primary mutation of the platelet-derived growth factor receptor α (PDGFRA). The approval was based on the NAVIGATOR trial, which revealed overall response rates of more than 90%. Despite this transformational activity, patients eventually progress, mostly due to acquired resistance mutations or following discontinuation due to neuro-cognitiv...
In driver monitoring various data types are collected from drivers and used for interpreting, modeling, and predicting driver behavior, and designing interactions. Aim of this contribution is to introduce manD 1.0, a multimodal dataset that can be used as a benchmark for driver monitoring in the context of automated driving. manD is the short form of human dimension in automated driving. manD 1.0 refers to a dataset that contains data from multiple driver monitoring sensors collected from 50 ...
Anomaly detection becomes essential across diverse domains. Data is usually collected sequentially in real-world applications such as sensor records and network logs. Consequently, a major challenge in anomaly detection is the real-time volatile sequential abnormal events. Recent research on time series has gained supreme advancements, leveraging the vast development of deep models like recurrent neural networks and transformers. However, most existing deep models focus on static time se...
Modern computer Technologies are skyrocketing to spheres, which frequently seemed unimaginable years ago. Quantum effect petabyte-sized storage devices or deep cache hierarchies, acting within nanoseconds, make only a few examples. At the same time, interfaces to communicate with such technologies are settled and remain largely unaffected by the technology development. While loading and storing a word to a given memory address was the standard interface to communicate with memory devices in v...
Die Stadtentwicklung in Deutschland steht vor einer doppelten Herausforderung: Einerseits der wachsende Bedarf an Wohnraum und andererseits die zunehmende Komplexität, die durch soziale und ökologische Anforderungen entsteht, wie die Förderung von Nachhaltigkeit und gemeinwohlorientierter Stadtentwicklung. Quartiere spielen als Lösungsebene eine entscheidende Rolle, da sie nicht nur Wohnraum bieten, sondern auch als Kernelemente für soziale Interaktion und ökologische Nachhaltigkeit in Städte...
This thesis focuses on the study of tree-based ensemble learners, with particular attention to their behavior as a prediction tool for multivariate or time-dependent outcomes and their implementation for efficient execution. In particular, well-known examples such as Random Forest and Extra Trees are often used for the prediction of univariate outcomes. However, for multivariate outcomes, the question arises whether it is better to fit univariate models separately or to follow a multivariate ...
Dose-response modeling occurs in many application areas and has a rich research history. An extensively studied application feld is clinical studies, where dose-response modeling is used in Phase II studies to identify the dose closest to a pre-defned effect. Many non-clinical, toxicological studies also aim at identifying a dose-response relationship. However, for non-clinical or toxicological studies there are fewer regulations or guidelines. This leads to a gap between nowadays research ad...
Nonlinear optical signals in optically driven quantum systems can reveal coherences and thereby open up the possibility for manipulation of quantum states. While the limiting cases of ultrafast and continuous-wave excitation have been extensively studied, the time dynamics of finite pulses bear interesting phenomena. In this paper, we explore the nonlinear optical probe signals of a two-level system excited with a laser pulse of finite duration. In addition to the prominent Mollow peaks, the ...
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