Langanzeige der Metadaten
DC Element | Wert | Sprache |
---|---|---|
dc.contributor.author | Arai, Toru | de |
dc.contributor.author | Hirata, Haruhiko | de |
dc.contributor.author | Hoshino, Shigenori | de |
dc.contributor.author | Inoue, Koji | de |
dc.contributor.author | Kawase, Ichiro | de |
dc.contributor.author | Kida, Hiroshi | de |
dc.contributor.author | Kijima, Takashi | de |
dc.contributor.author | Kumagai, Toru | de |
dc.contributor.author | Osaki, Tadashi | de |
dc.contributor.author | Tachibana, Isao | de |
dc.contributor.author | Takimoto, Takayuki | de |
dc.contributor.author | Yanagita, Masahiko | de |
dc.contributor.author | Yano, Yukihiro | de |
dc.contributor.author | Yoshida, Mitsuhiro | de |
dc.date.accessioned | 2008-06-17T13:57:51Z | - |
dc.date.available | 2008-06-17T13:57:51Z | - |
dc.date.issued | 2005-08-11 | de |
dc.identifier.issn | 1611-2156 | de |
dc.identifier.uri | http://hdl.handle.net/2003/25650 | - |
dc.identifier.uri | http://dx.doi.org/10.17877/DE290R-8281 | - |
dc.description.abstract | Transforming growth factor-ß (TGF-ß) is a key factor for understanding the pathogenesis of fibrotic disorders such as idiopathic pulmonary fibrosis (IPF). We have demonstrated that interleukin-10 (IL-10) suppresses TGF-ß-induced expression of type I collagen (COL1) mRNA in a human lung fibroblast cell line (WI-38). However, the inhibitory mechanism has not yet been clearly elucidated. Thus, in the current study, we investigate the effects of IL-10 blockade of TGF-ß signaling which regulates COL1 mRNA expression. In WI-38 cells, IL-10 inhibits TGF-ß-mediated phosphorylation of both, c-Jun HN2-terminal kinase (JNK) and p38, but does not suppress TGF-ß- mediated phosphorylation of Smad2 or affect TGF-ß-upregulation of Smad7 mRNA expression. In addition, SP600125 and SB203580, specific inhibitors of JNK and p38, respectively, attenuate TGF-ß-induced COL1 mRNA expression in WI-38 cells. These results suggest that IL-10 inhibits TGF-ß-induced COL1 mRNA expression via both JNK and p38 pathways but not Smad pathways in WI-38 cells. This inhibitory mechanism may provide a novel insight into therapeutic strategies for fibrotic disorders such as IPF. | en |
dc.language.iso | en | de |
dc.relation.ispartofseries | EXCLI Journal ; Vol. 4, 2005 | en |
dc.subject | collagen | en |
dc.subject | IL-10 | en |
dc.subject | JNK | en |
dc.subject | Smad | en |
dc.subject | TGF-ß | en |
dc.subject.ddc | 610 | - |
dc.title | IL-10 Inhibits Transforming Growth Factor-ß-Induction of Type I Collagen mRNA Expression via Both JNK and p38 Pathways in Human Lung Fibroblasts | en |
dc.type | Text | de |
dc.type.publicationtype | article | de |
dcterms.accessRights | open access | - |
eldorado.dnb.zdberstkatid | 2132560-1 | - |
Enthalten in den Sammlungen: | Original Articles |
Dateien zu dieser Ressource:
Datei | Beschreibung | Größe | Format | |
---|---|---|---|---|
Yoshida07-05proof.pdf | DNB | 318.98 kB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource ist urheberrechtlich geschützt. |
Diese Ressource ist urheberrechtlich geschützt.
rightsstatements.org