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DC Element | Wert | Sprache |
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dc.contributor.author | Limnusont, Phattrapoom | - |
dc.contributor.author | Pingaew, Ratchanok | - |
dc.contributor.author | Prachayasittikul, Supaluk | - |
dc.contributor.author | Prachayasittikul, Virapong | - |
dc.contributor.author | Ruchirawat, Somsak | - |
dc.date.accessioned | 2009-03-11T10:24:01Z | - |
dc.date.available | 2009-03-11T10:24:01Z | - |
dc.date.issued | 2009-03-11T10:24:01Z | - |
dc.identifier.uri | http://hdl.handle.net/2003/26038 | - |
dc.identifier.uri | http://dx.doi.org/10.17877/DE290R-14331 | - |
dc.description.abstract | An array of interesting activities for bioactive 3-substituted thiopyridines have previously been reported. Herein, a series of α- and β-(1-adamantylthio) analogs of 3-picoline and phenylpyridines were prepared and investigated for antimicrobial (agar dilution method against 21 strains of microorganisms) and antimalarial (against P. falciparum) activities. It was found that β-thiopyridines, 5-(1-adamantylthio)-3-picoline (7) and 3-(1-adamantylthio)-4-phenylpyridine (8) are novel antimicrobials and antimalarials. Significantly, analogs 7 and 8 are very potent antimicrobials with MIC range of 2-32 µg/mL where 8 being the most potent. The β-sulfides 7 and 8 selectively inhibited the growth of tested gram-positive bacteria, but inactive against gram-negative bacilli including the members of Enterobacteriaceae. This study identified new antimicrobials that represent promising lead compounds suitable for fur-ther preclinical and clinical development. | en |
dc.language.iso | en | - |
dc.relation.ispartofseries | EXCLI Journal ; Vol. 8, 2009 | en |
dc.subject | 1-adamantylthio | en |
dc.subject | 3-picoline | en |
dc.subject | antimalarials | en |
dc.subject | antimicrobials | en |
dc.subject | phenylpyridines | en |
dc.subject.ddc | 610 | - |
dc.title | Beta-(1-adamantylthio)pyridine analogs as antimicrobials and antimalarials | en |
dc.type | Text | - |
dc.type.publicationtype | article | - |
dcterms.accessRights | open access | - |
eldorado.dnb.zdberstkatid | 2132560-1 | - |
Enthalten in den Sammlungen: | Original Articles |
Dateien zu dieser Ressource:
Datei | Beschreibung | Größe | Format | |
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Prachayasittikul_antimicrobials_proof.pdf | DNB | 268.6 kB | Adobe PDF | Öffnen/Anzeigen |
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