Autor(en): | Abdel Salam, Omar M. E. Shaffie, Nermeen M. Sleem, Amany A. |
Titel: | Hepatoprotective effects of citric acid and aspartame on carbon tetrachloride-induced hepatic damage in rats |
Sprache (ISO): | en |
Zusammenfassung: | The aim of this study was to investigate the effect of citric acid or the sweetening agent aspartame on the CCl4-induced hepatic injury in rats. Citric acid (10 mg/kg, 100 mg/kg or 1000 mg/kg), aspartame (0.625 or 1.25 mg/kg) or silymarin (25 mg/kg) was given once daily orally simultaneously with CCl4 and for one week thereafter. The administration of citric acid at 100 mg/kg or 1000 mg/kg to CCl4-treated rats reduced elevated plasma ALT by 44.1-63.3 %, AST by 47.8-70.6 %, ALP by 41.7-67.2 %, respectively compared to controls. Aspartame at 0.625 or 1.25 mg/kg reduced plasma ALT by 39.8-52.0 %, AST by 43.2-52.4 % and ALP by 50.0-68.5 %, respectively. Meanwhile, silymarin at 25 mg/kg reduced ALT, AST and ALP levels by 52.7, 62.2 and 64.7 %, respectively. On histology, citric acid at 1000 mg/kg resulted in near normalization of liver tissue. Vacuolar degeneration and necrosis were markedly reduced by 1.25 mg/kg aspartame. These results indicate that treatment with citric acid or the sweetening agent aspartame protects against hepatocellular necrosis induced by CCl4. |
Schlagwörter: | acute hepatic injury aspartame carbon tetrachloride citric acid rat silymarin |
URI: | http://hdl.handle.net/2003/26039 http://dx.doi.org/10.17877/DE290R-15693 |
Erscheinungsdatum: | 2009-03-11T10:24:25Z |
Enthalten in den Sammlungen: | Original Articles |
Dateien zu dieser Ressource:
Datei | Beschreibung | Größe | Format | |
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Abdel_Salam_hepatoprotective_proof.pdf | DNB | 352.59 kB | Adobe PDF | Öffnen/Anzeigen |
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