Authors: | Pingaew, Ratchanok Prachayasittikul, Supaluk Prachayasittikul, Virapong Ruchirawat, Somsak Worachartcheewan, Apilak |
Title: | A new sulfoxide analog of 1,2,3,6-tetrahydrophenylpyridine and antimicrobial activity |
Language (ISO): | en |
Abstract: | Bioactivities of thiotetrahydropyridines were previously described. Herein, a novel bioactive sulfoxide analog; N-acetyl-2-(1-adamantylsulfoxo)-3-acetoxy-4-phenyl-6-hydroxy-1,2,3,6-tetrahydropyridine (3) from the deoxydative substitution of 4-phenylpyridine 1-oxide is reported. Its structure was elucidated using spectral data including 2D-NMR, MS, IR and UV. The sulfoxide 3 exhibited antibacterial activity against Moraxella catarrhalis and Streptococcus pyogenes with minimum inhibitory concentration of 128 and 256 μg/mL, respectively. |
Subject Headings: | 4-phenylpyridine l-oxide antimicrobial activity sulfonium ion sulfoxide tetrahydropyridine |
URI: | http://hdl.handle.net/2003/27472 http://dx.doi.org/10.17877/DE290R-15807 |
Issue Date: | 2010-11-17 |
Appears in Collections: | Original Articles |
Files in This Item:
File | Description | Size | Format | |
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Prachayasittikul_270910_proof.pdf | DNB | 201.81 kB | Adobe PDF | View/Open |
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