Authors: | Mansour, Heba Hosny |
Title: | Protective effect of ginseng against gamma-irradiation-induced oxidative stress and endothelial dysfunction in rats |
Language (ISO): | en |
Abstract: | This study investigated the potential protective effects of ginseng on gamma-irradiation-induced oxidative stress and endothelial dysfunction in rats. Twenty four male albino rats were divided into four groups. In the control group, rats were administered vehicle by tube for 7 consecutive days. The second group was administered ginseng extract (100 mg/kg, by gavage) for 7 consecutive days. Animals in the third group were administered vehicle by tube for 7 consecutive days, then exposed to single dose gamma-irradiation (6 Gy). The Fourth group received ginseng extract for 7 consecutive days, one hour later rats were exposed to gamma-irradiation. Oral administration of ginseng extract prior to irradiation produced a significant protection which was evidenced by a significant reduction in serum creatine kinase (CPK) and lactate dehydrogenase (LDH) activities and asymmetric dimethylarginine (ADMA), urea and creatinine levels with significant increase in serum total nitrate/nitrite (NO(x)) level. Moreover, ginseng significantly increased cardiac and renal superoxide dismutase (SOD) and glutathione peroxidase (GSHPx) activities, and reduced glutathione (GSH) content, associated with a significant depletion in malondialdehyde (MDA) and NO(x) levels compared to irradiated group. This study suggests that ginseng may serve as a potential protective agent against gamma-irradiation-induced cardio-nephrotoxicity via enhancing the antioxidant activity and inhibition of endothelial dysfunction. |
Subject Headings: | ginseng gamma-radiation asymmetric dimethylarginine nitric oxide oxidative stress rats |
URI: | http://hdl.handle.net/2003/32957 http://dx.doi.org/10.17877/DE290R-7361 |
Issue Date: | 2013-08-30 |
Appears in Collections: | Original Articles |
Files in This Item:
File | Description | Size | Format | |
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Mansour_30082013_proof.pdf | DNB | 183.27 kB | Adobe PDF | View/Open |
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