Authors: | Ye, Xiaofeng Kong, Wen Zafar, Mohammad Ishraq Zeng, Junchao Yang, Rui Chen, Lu-Lu |
Title: | Plasma vascular endothelial growth factor B is elevated in non-alcoholic fatty liver disease patients and associated with blood pressure and renal dysfunction |
Language (ISO): | en |
Abstract: | Vascular endothelial growth factor B (VEGF-B) is a critical metabolic regulator in insulin resistance, and lipid distribution. We intended to ascertain the relationship between circulating VEGF-B and non-alcoholic fatty liver disease (NAFLD) in the general public. We recruited a total of 194 general participants for a routine physical health examination; of these, 84 participants were identified with NAFLD and 110 without NAFLD based on ultrasonographic findings. Homeostasis model assessment of insulin resistance (HOMA-IR), body mass index (BMI), HbA1c, liver function, kidney function, plasma VEGF-B levels and indexes of metabolic syndrome (blood pressure, fasting plasma glucose, fasting lipids) were evaluated. Plasma VEGF-B values were significantly higher in individuals with NAFLD compared to those without NAFLD (P = 0.022), and analysis of covariance confirmed this result. VEGF-B showed a positive correlation with γ-glutamyl transpeptidase (γ-GT) and HOMA-IR in univariate analysis (q = 0.242; P = 0.001; q =0.174; P = 0.019, respectively). Multiple linear regression analysis showed that γ-GT and ALT were independently correlated with VEGF-B even after adjusted for gender and age (q = 0.286; P = 0.01; q =0.237; P = 0.033, respectively). Moreover, plasma VEGF-B showed a powerful correlation with blood pressure and renal dysfunction. Plasma VEGF-B might be a new clinical variable related to NAFLD and could be a proper biomarker for the early detection of hypertension and renal dysfunction. However, further studies with large cohorts’ size are warranted to validate our findings. |
Subject Headings: | Vascular endothelial growth factor B Non-alcoholic fatty liver disease Blood pressure Renal dysfunction Metabolism |
URI: | http://hdl.handle.net/2003/39886 http://dx.doi.org/10.17877/DE290R-21777 |
Publishers Link: | https://doi.org/10.17179/excli2020-2647 |
Issue Date: | 2020-08-20 |
Rights link: | https://creativecommons.org/licenses/by/4.0/ |
Provenance: | IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund |
Citation: | Ye, X., Kong, W., Zafar, M. I., Zeng, J., Yang, R. ., & Chen, L.-L. (2020). Plasma vascular endothelial growth factor B is elevated in non-alcoholic fatty liver disease patients and associated with blood pressure and renal dysfunction. EXCLI Journal, 19. 2020, 186-1195. https://doi.org/10.17179/excli2020-2647 |
Appears in Collections: | Original Articles 2020 |
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