Authors: | Bobers, Jens Hahn, Lisa Katharina Averbeck, Tobias Brunschweiger, Andreas Kockmann, Norbert |
Title: | Reaction optimization of a Suzuki‐Miyaura cross‐coupling using design of experiments |
Language (ISO): | en |
Abstract: | The combination of lab automation and design of experiments for the execution of screening experiments increases productivity and reduces error-prone manual work. A self-developed software tool allows for creating fractional-factorial experimental design (FFED). Application of FFED on the screening of a Suzuki-Miyaura cross-coupling leads to a 93 % reduced design compared to full-factorial design. The resulting regression model qualitatively shows the positive effect of educt concentrations, time, and temperature and reveals the decrease in conversion at high base concentrations. |
Subject Headings: | Design of experiments Lab automation Reaction optimization Suzuki-Miyaura reaction |
Subject Headings (RSWK): | Versuchsplanung Labortechnik Automation Reaktionsoptimierung Suzuki-Miyaura-Reaktion |
URI: | http://hdl.handle.net/2003/42369 http://dx.doi.org/10.17877/DE290R-24206 |
Issue Date: | 2022-03-11 |
Rights link: | https://creativecommons.org/licenses/by/4.0/ |
Appears in Collections: | Arbeitsgruppe Apparatedesign |
Files in This Item:
File | Description | Size | Format | |
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Chemie Ingenieur Technik - 2022 - Bobers - Reaction Optimization of a Suzuki‐Miyaura Cross‐Coupling Using Design of.pdf | DNB | 4.21 MB | Adobe PDF | View/Open |
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