Autor(en): | Mawick, Matthias Jaworski, Carolin Bittermann, Jens Iovkova, Ljuba Pu, Yinglan Wängler, Carmen Wängler, Björn Jurkschat, Klaus Krause, Norbert Schirrmacher, Ralf |
Titel: | CycloSiFA: the next generation of silicon-based fluoride acceptors for positron emission tomography (PET) |
Sprache (ISO): | en |
Zusammenfassung: | The ring-opening Si-fluorination of a variety of azasilole derivatives cyclo-1-(iPr2Si)−4-X−C6H3−2-CH2NR (4: R=2,6-iPr2C6H3, X=H; 4 a: R=2,4,6-Me3C6H2, X=H; 9: R=2,6-iPr2C6H3, X=tBuMe2SiO; 10: R=2,6-iPr2C6H3, X=OH; 13: R=2,6-iPr2C6H3, X=HCCCH2O; 22: R=2,6-iPr2C6H3, X=tBuMe2SiCH2O) with different 19F-fluoride sources was studied, optimized and the experience gained was used in a translational approach to create a straightforward 18F-labelling protocol for the azasilole derivatives [18F]6 and [18F]14. The latter constitutes a potential clickable CycloSiFA prosthetic group which might be used in PET tracer development using Cu-catalysed triazole formation. Based on our findings, CycloSiFA has the potential to become a new entry into non-canonical labelling methodologies for radioactive PET tracer development. |
Schlagwörter: | Azasilole Fluorine Positron emission tomography Ring opening Silicon |
URI: | http://hdl.handle.net/2003/42661 http://dx.doi.org/10.17877/DE290R-24497 |
Erscheinungsdatum: | 2023-10-18 |
Rechte (Link): | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
Enthalten in den Sammlungen: | Lehrstühle für Anorganische Chemie |
Dateien zu dieser Ressource:
Datei | Beschreibung | Größe | Format | |
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Angew Chem Int Ed - 2023 - Mawick - CycloSiFA The Next Generation of Silicon‐Based Fluoride Acceptors for Positron.pdf | DNB | 4.08 MB | Adobe PDF | Öffnen/Anzeigen |
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