Authors: | Biedermann, Stefanie Dette, Holger Zhu, Wei |
Title: | Optimal Designs for Dose-Response Models with Restricted Design Spaces |
Language (ISO): | en |
Abstract: | In dose response studies, the dose range is often restricted due to concerns over drug toxicity and/or efficacy. We present restricted and unrestricted interval locally optimal designs with respect to a very general class of optimality criteria for estimating the underlying dose response curve. The underlying curve belongs to a diversified set of link functions suitable for the dose response studies and having a common canonical form. These include the fundamental binary response models – the logit and the probit as well as the skewed versions of these models. The results are illustrated through the re-design of a dose ranging trial conducted at the Merck Research Laboratories (Zeng and Zhu, 1997). This work is a generalization of the results of Dai and Zhu (2002) in terms of the design interval, the underlying dose response curve and the optimality criterion. |
Subject Headings: | binary response model dose ranging dose response link function general equivalence theorem locally compound optimal design information function matrix mean |
URI: | http://hdl.handle.net/2003/4911 http://dx.doi.org/10.17877/DE290R-5411 |
Issue Date: | 2004 |
Provenance: | Universitätsbibliothek Dortmund |
Appears in Collections: | Sonderforschungsbereich (SFB) 475 |
Files in This Item:
File | Description | Size | Format | |
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40_04.pdf | DNB | 216.04 kB | Adobe PDF | View/Open |
tr40-04.ps | 447.35 kB | Postscript | View/Open |
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