Autor(en): | Degen, Gisela H. Selinski, Silvia |
Titel: | Estimation of the Mean AUC of the Xenoestrogens Daidzein, Bisphenol A, and p-tert-Octylphenol |
Sprache (ISO): | en |
Zusammenfassung: | Potentially adverse human and environmental effects due to hormone mimicry of environmental estrogens are a matter of current concern. Environmental estrogens belong to the so-called endocrine active compounds (EAC), which alter signalling processes of the endocrine system leading to a broad range of effects during foetal and postnatal development, puberty, adulthood, and aging. A number of synthetic chemicals as well as several plant-derived compounds, so-called phytoestrogens, are known to have weak estrogenic activity. The present study is part of the risk assessment of the weak environmental estrogens daidzein, p-tert-octylphenol, and bisphenol A. The isoflavone daidzein is an important phytoestrogen with respect to dietary exposure (soy beans and soy products). p-tert-Octylphenol and bisphenol A are industrial chemicals. The toxicokinetics and the bioavailability of these three substances in female DA/Han rats after oral and single intravenous application were investigated by the use of population models accounting for the differences in the individual metabolism. Furthermore, populations of pregnant and non-pregnant rats are compared. |
Schlagwörter: | Bisphenol A daidzein p-tert-octylphenol xenoestrogens phytoestrogens endocrine active compounds bioavailability AUC population model EM algorithm Mann-Whitney-U-test |
URI: | http://hdl.handle.net/2003/4928 http://dx.doi.org/10.17877/DE290R-6944 |
Erscheinungsdatum: | 2003 |
Provinienz: | Universitätsbibliothek Dortmund |
Enthalten in den Sammlungen: | Sonderforschungsbereich (SFB) 475 |
Dateien zu dieser Ressource:
Datei | Beschreibung | Größe | Format | |
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05_03.pdf | DNB | 129.95 kB | Adobe PDF | Öffnen/Anzeigen |
tr05-03.ps | 440.07 kB | Postscript | Öffnen/Anzeigen |
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