Authors: Suter, Dieter
Pieper, Thorsten
Markova, Svetlana
Kinjo, Masataka
Title: Effect of cholesterol on diffusion in surfactant bilayers
Language (ISO): en
Abstract: Biological membranes consist of lipid bilayers with liquid-ordered and liquid-disordered phases. It is believed that cholesterol controls the size of the microdomains in the liquid-ordered phase and thereby affects the mobility as well as the permeability of the membrane. We study this process in a model system consisting of the nonionic surfactant C12E5 and water in the lamellar phase. We measure the diffusion of fluorescent probe molecules (rhodamine B) by fluorescence correlation spectroscopy. For different surfactant to water ratios, we measure how the molecular mobility varies with the amount of cholesterol added. We find that a reduction of the diffusion coefficient is already detectable at a molar ratio of 8 mol % cholesterol.
URI: http://hdl.handle.net/2003/25027
http://dx.doi.org/10.17877/DE290R-3448
Publishers Link: http://e3.physik.tu-dortmund.de/~suter/eprints/MembraneDiffusion.pdf
Issue Date: 2007-10-29
Rights: ©2007 American Institute of Physics
Publisher: American Institute of Physics
URL: http://link.aip.org/link/?JCPSA6/127/165102/1
Citation: T. Pieper, S. Markova, M. Kinjo, and D. Suter: Effect of cholesterol on diffusion in surfactant bilayers. In: J. Chem. Phys. 127, 165102 (2007).
Appears in Collections:Suter, Dieter Prof. Dr.

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