Authors: | Arand, Michael Cronin, Annette Hengstler, Jan G. Herrero Plana, Maria Elena Lohmann, Matthias Oesch, Franz |
Title: | Detoxification Strategy of Epoxide Hydrolase |
Other Titles: | The Basis for a Threshold in Chemical Carcinogenesis |
Language (ISO): | en |
Abstract: | The human microsomal epoxide hydrolase, a single enzyme, has to detoxify a broad range of structurally diverse, potentially genotoxic epoxides that are formed in the course of xenobiotic metabolism. The enzyme has developed a unique strategy to combine a broad substrate specificity with a high detoxification efficacy, by immediately trapping the reactive compounds as covalent intermediates and by being expressed at high levels for high trapping capacity. Computer simulation and experimental data as well as existing epidemiologic studies reveal this detoxification strategy as the mechanistic basis for a threshold in the tumorigenesis of mutagenic carcinogens. |
Subject Headings: | computer simulation enzyme kinetics genotoxic mechanism structure |
URI: | http://hdl.handle.net/2003/25628 http://dx.doi.org/10.17877/DE290R-117 |
Issue Date: | 2003-03-13 |
Appears in Collections: | Original Articles |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Arand.pdf | DNB | 393.18 kB | Adobe PDF | View/Open |
Simulation.zip | 1.75 MB | zip | View/Open |
This item is protected by original copyright |
This item is protected by original copyright rightsstatements.org