Autor(en): | Arand, Michael Cronin, Annette Hengstler, Jan G. Herrero Plana, Maria Elena Lohmann, Matthias Oesch, Franz |
Titel: | Detoxification Strategy of Epoxide Hydrolase |
Sonstige Titel: | The Basis for a Threshold in Chemical Carcinogenesis |
Sprache (ISO): | en |
Zusammenfassung: | The human microsomal epoxide hydrolase, a single enzyme, has to detoxify a broad range of structurally diverse, potentially genotoxic epoxides that are formed in the course of xenobiotic metabolism. The enzyme has developed a unique strategy to combine a broad substrate specificity with a high detoxification efficacy, by immediately trapping the reactive compounds as covalent intermediates and by being expressed at high levels for high trapping capacity. Computer simulation and experimental data as well as existing epidemiologic studies reveal this detoxification strategy as the mechanistic basis for a threshold in the tumorigenesis of mutagenic carcinogens. |
Schlagwörter: | computer simulation enzyme kinetics genotoxic mechanism structure |
URI: | http://hdl.handle.net/2003/25628 http://dx.doi.org/10.17877/DE290R-117 |
Erscheinungsdatum: | 2003-03-13 |
Enthalten in den Sammlungen: | Original Articles |
Dateien zu dieser Ressource:
Datei | Beschreibung | Größe | Format | |
---|---|---|---|---|
Arand.pdf | DNB | 393.18 kB | Adobe PDF | Öffnen/Anzeigen |
Simulation.zip | 1.75 MB | zip | Öffnen/Anzeigen |
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