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DC Element | Wert | Sprache |
---|---|---|
dc.contributor.author | Berman, A. E. | de |
dc.contributor.author | Chubukina, A. N. | de |
dc.contributor.author | Kozlova, N. I. | de |
dc.contributor.author | Morozevich, G. E. | de |
dc.contributor.author | Shtil, A. A. | de |
dc.date.accessioned | 2008-06-17T13:46:31Z | - |
dc.date.available | 2008-06-17T13:46:31Z | - |
dc.date.issued | 2004-10-11 | de |
dc.identifier.issn | 1611-2156 | de |
dc.identifier.uri | http://hdl.handle.net/2003/25638 | - |
dc.identifier.uri | http://dx.doi.org/10.17877/DE290R-337 | - |
dc.description.abstract | The aim of the study was to investigate the role of integrins in anchorage dependent apoptosis (anoikis) and in vitro invasion of human breast cancer cell line MCF-7 and its multidrug resistant subline MCF-7Dox. Acquisition of MDR was associated with markedly decreased expression of collagen specific a2ß1 and avß3 integrins, laminin specific a3ß1 and a6ß1 receptors and dramatic up-regulation of fibronectin specific a5ß1 integrin. The MDR subline was substantially more resistant to anoikis than their wild type counterparts. Furthermore, MCF-7Dox cells secreted MMP-9 collagenase and invaded Matrigel. We demonstrate for the first time that stimulation of ß1 integrin signaling strongly sensitizes MCF-7 cells to anoikis. | en |
dc.language.iso | en | de |
dc.relation.ispartofseries | EXCLI Journal ; Vol. 3, 2004 | en |
dc.subject | anoikis | en |
dc.subject | integrins | en |
dc.subject | multidrug resistance | en |
dc.subject | tumor invasion | en |
dc.subject.ddc | 610 | - |
dc.title | Expression of Integrins, Anchorage Dependent Apoptosis and Invasiveness of Multidrug Resistant Human Breast Carcinoma Cells | en |
dc.type | Text | de |
dc.type.publicationtype | article | de |
dcterms.accessRights | open access | - |
eldorado.dnb.zdberstkatid | 2132560-1 | - |
Enthalten in den Sammlungen: | Original Articles |
Dateien zu dieser Ressource:
Datei | Beschreibung | Größe | Format | |
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Berman09-04proofrev.pdf | DNB | 568.36 kB | Adobe PDF | Öffnen/Anzeigen |
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