Therapeutic potential of peripheral blood stem cell transplantation in one cirrhotic patient caused by HBV combined with HCV

Abstract

Stem cell based therapy was very attractive in decompensated liver cirrhosis currently. The possible mechanism might be due to its potential to help tissue regeneration with minimally invasive procedures. Here we report the case of a 44-year-old man, infected by hepatitis B virus (HBV) combined with hepatitis C virus (HCV) for longer than 10 years, who eventually developed decompensated liver cirrhosis. After being infused with mobilized peripheral blood stem cells, the patient showed significantly elevated serum albumin level, cholesterol (CHO), cholinesterase (CHE) and decreased PT (prothrombin time) during the 26 months of follow-up. To our knowledge, this is the first case of transplanting mobilized PBSCs to treat the HBV combined with HCV related decompensated liver cirrhosis.