Authors: Ansarullah
Devkar, Ranjitsinh
Jadeja, Ravirajsinh
Ramachandran, A. V.
Thounaojam, Menaka
Title: Oreocnide integrifolia (Gaud.)Miq. exhibits hypoglycemic and hypolipidemic potentials on streptozotocin diabetic rats
Other Titles: a preliminary dose and duration dependent study
Language (ISO): en
Abstract: Oreocnide integrifolia (Gaud.)Miq (Urticaceae) leaves are used to alleviate diabetic symptoms in folk medicine in northeast India. In the present study, dose and duration dependent hypoglycemic potentials were evaluated in streptozotocin induced diabetic rats. Administration of aqueous leaf extract (100, 250, 500 and 750 mg/kg body weight orally once daily) to diabetic rats reduced glycemic levels by 56 % by 4 weeks of treatment and was comparable to standard reference drug Metformin. The experimental data also revealed significant improvement in lowering lipid profile, Urea, Creatinine, Hb, HbA1c and insulin levels. The present study clearly demonstrates hypoglycemic and hypolipidemic potential of Oreocnide integrifolia leaf extract.
Subject Headings: insulin
Oreocnide integrifolia
Issue Date: 2009-07-08T07:20:38Z
Appears in Collections:Original Articles

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