Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Guo, Jia | - |
dc.contributor.author | Wang, Myeong-Hyeon | - |
dc.date.accessioned | 2009-07-08T07:27:52Z | - |
dc.date.available | 2009-07-08T07:27:52Z | - |
dc.date.issued | 2009-07-08T07:27:52Z | - |
dc.identifier.uri | http://hdl.handle.net/2003/26221 | - |
dc.identifier.uri | http://dx.doi.org/10.17877/DE290R-7314 | - |
dc.description.abstract | The cytotoxicity and mechanism of cell death induced by an extract of Ulmus davidiana Planch (UDP) were investigated. A 70 % ethanol extract of UDP exerted cytotoxic effects on HepG2 cells in a time- and dose-dependent manner caused a significant dose-dependent increase in the number of apoptotic cells. In addition, obvious shrinkage and destruction of the monolayer were observed in UDP-treated cells, but not in untreated cells. RT-PCR analysis revealed that the mRNA expression of p53 and c-myc was markedly increased in cells treated with the plant extract. In contrast, caspase-3 expression was induced after 1 h of incubation and then decreased at 3 h; however, it subsequently increased and remained at a relatively high level thereafter. Our data suggest the presence of a bioactive compound capable of killing liver carcinoma cells by apoptosis in a 70 % ethanol extract of UDP, and that the mechanism of apoptosis in the HepG2 cells included p53 and c-myc signaling. | en |
dc.language.iso | en | - |
dc.relation.ispartofseries | EXCLI Journal ; Vol. 8, 2009 | en |
dc.subject | 70 % ethanol extract | en |
dc.subject | apoptosis | en |
dc.subject | HepG2 | en |
dc.subject | Ulmus davidiana Planch | en |
dc.subject.ddc | 610 | - |
dc.title | Extract of Ulmus davidiana Planch barks induced apoptosis in human hepatoma cell line HepG2 | en |
dc.type | Text | - |
dc.type.publicationtype | article | - |
dcterms.accessRights | open access | - |
eldorado.dnb.zdberstkatid | 2132560-1 | - |
Appears in Collections: | Original Articles |
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Guo_Wang_ethanol_extract_220609_proof.pdf | DNB | 494.7 kB | Adobe PDF | View/Open |
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