Authors: | Dette, Holger Pepelyshev, Andrey Wong, Weng Kee |
Title: | Optimal experimental design strategies for detecting hormesis |
Language (ISO): | en |
Abstract: | Hormesis is a widely observed phenomenon in many branches of life sciences ranging from toxicology studies to agronomy with obvious public health and risk assessment implications. We address optimal experimental design strategies for determining presence of hormesis in a controlled environment using the recently proposed Hunt-Bowman model. We propose alternative models that have an implicit hormetic threshold, discuss their advantages over current models, construct and study properties of optimal designs for (i) estimating model parameters, (ii) estimating the threshold dose, and (iii) testing for the presence of hormesis. We also determine maximin optimal designs that maximize the minimum of the design efficiencies when we have multiple design criteria or there is model uncertainty where we have a few plausible models of interest. We apply our optimal design strategies to a teratology study and show our proposed designs outperform the implemented design by a very wide margin for many situations. |
Subject Headings: | Continuous design Dose-response Hunt-Bowman model Logistic model Maximin design Quadratic-logistic model Weibull model |
URI: | http://hdl.handle.net/2003/27271 http://dx.doi.org/10.17877/DE290R-15375 |
Issue Date: | 2010-06-15 |
Appears in Collections: | Sonderforschungsbereich (SFB) 823 |
Files in This Item:
File | Description | Size | Format | |
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DP_2510_SFB823_dette_pepelyshev_wong.pdf | DNB | 204.65 kB | Adobe PDF | View/Open |
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