Authors: Li, Qing-Chan
Su, Jian-Yu
Zhu, Liang
Title: Evaluation of the in vivo anti-inflammatory activity of a flavone glycoside from Cancrinia discoidea (Ledeb.) Poljak
Language (ISO): en
Abstract: The anti-inflammatory effect of selagin-7-O-(6″-O-Acetyl-)-β-D-glucoside, isolated from the medicinal herb Cancrinia discoidea (Ledeb.) Poljak, was evaluated for its anti-inflammatory activity in the carrageenin- and serotonin-induced rat paw oedema models of acute inflammation and the cotton pellet-induced granuloma rat model of chronic inflammation. Flavone glycoside at doses of 5, 10, or 20 mg/kg, the clinical anti-inflammatory indo-methacin at 10 mg/kg, or vehicle were administered orally before injection of the pro-inflammatory compound. The test compound showed significant anti-inflammatory activity against paw edema induced by carrageenin or serotonin, most notably at the highest test dose of 20 mg/kg. In the cotton pellet-induced granuloma model, the compound showed dose-dependent anti-inflammatory activity, with the highest effect at 20 mg/kg. In all three assays, the flavone glucoside compound was more active at 20 mg/kg than indomethacin at 10 mg/kg.
Subject Headings: anti-inflammatory activity
Cancrinia discoidea (Ledeb.) Poljak
selagin-7-O-(6″-O-Acetyl-)-β-D-glucoside
URI: http://hdl.handle.net/2003/29028
http://dx.doi.org/10.17877/DE290R-8858
Issue Date: 2011-08-23
Appears in Collections:Original Articles

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