Authors: | Budin, Siti Balkis Idris, Muhd Hanis Md Mohamed, Jamaludin Osman, Mohamad |
Title: | Protective role of Hibiscus sabdariffa calyx extract against streptozotocin induced sperm damage in diabetic rats |
Language (ISO): | en |
Abstract: | Diabetes mellitus contributes to male sexual dysfunction and infertility by modulating oxidative damage. To date, a number of studies have demonstrated antioxidant properties of Hibiscus sabdariffa Linn. This study was designed to investigate the effects of H. sabdariffa UKMR-2 variety on sperm functioning of streptozotocin-induced diabetic rats. Male Sprague-Dawley rats were allotted into four groups, namely control group (C), H. sabdariffa extract (HSE) group, diabetes group (D) and diabetes plus HSE group (D+HSE). HSE (100 mg/kg/body weight) was administered orally for 28 consecutive days. After 28-days of supplementation, the rats were sacrificed to obtain epididymal sperm. Administration of HSE significantly lowered the level of fasting blood glucose and increased plasma insulin level in D+HSE group as compared to D group (p<0.05). Sperm quality in the D+HSE group was improved with significantly higher sperm concentrations (p<0.05) and sperm motility (p<0.001) as well as lower percentage of sperm abnormality (p<0.05) as compared to the diabetic group. Plasma follicle-stimulating hormone (FSH) level was significantly elevated (p<0.05) in D+HSE group than in D group while no significant alteration in plasma testosterone and luteinizing hormone (LH) level were seen between groups. In conclusion, this study suggested that H. sabdariffa UKMR-2 variety has a potential protective role against diabetes-induced sperm damage. |
Subject Headings: | diabetes Hibiscus sabdariffa UKMR-2 oxidative stress sperm damage |
URI: | http://hdl.handle.net/2003/29784 http://dx.doi.org/10.17877/DE290R-5145 |
Issue Date: | 2012-11-16 |
Appears in Collections: | Original Articles |
Files in This Item:
File | Description | Size | Format | |
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Idris_19092012_proof.pdf | DNB | 187.44 kB | Adobe PDF | View/Open |
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