Extract of Ferula foetida regel reverses gentamicin-induced nephrotoxicity in rats

Abstract

Natural products and dietary components have earlier been proven as potential chemoprotective agents, and continuous efforts are in progress to search for such new products. Gentamicin, an aminoglycoside antibiotic, is widely used for treating the infections caused by many gram negative bacteria. However, besides other unwanted effects, the drug causes tubular cell necrosis in the proximal convoluted tubules of nephrons. Unavailability of any remedial measures in the modern medicine for such ailments therefore makes it imperative to screen for natural products that are nephroprotective against such renal impairment. Here in the undertaken study, we have tested nephroprotective effects of Hing (Ferula foetida) extracts on gentamicin-treated rats. As expected, subcutaneous administration of rats with Gentamicin (100 mg/kg) showed significant increase in blood urea nitrogen (BUN), serum creatinine and thiobarbituric acid reacting substances (TBARS), as an indication of renal disorder. However, co-administration of methanol soluble and insoluble fractions of Ferula foetida (Hing), to the Gentamicin-treated rats almost showed a complete reversal of the above effects, indicating nephroprotective properties of the herbal drug. This may be an important addition to the list of studies where natural products have been discovered to be chemoprotective.