Authors: | Ahmadi, Mahboubeh Yeganeh Haj Badinloo, Marziyeh Joukar, Siyavash Mirzaeipour, Fateme Najafipour, Hamid Nasri, Hamidreza |
Title: | Modulatory effect of semelil (ANGIPARS™) on isoproterenol induced cardiac injury |
Language (ISO): | en |
Abstract: | Administration of semelil (ANGIPARS™) has been successful in the treatment of diabetic foot ulcer. Considering the improvement of blood flow and anti-inflammatory effect that are attributed to this drug, we investigated its effect on cardiovascular performance in rabbits with isoproterenol (ISO) induced myocardial injury. Animal groups included: control group; ISO group, received ISO 50 mg/kg s.c. for two consecutive days; S1+ISO, S5+ISO and S10+ISO groups, received semelil 1, 5, and 10 mg/kg/day i.p. respectively, 30 min before ISO. On the 3rd day, electrocardiogram (ECG) and hemodynamic parameters were recorded; blood samples were taken and hearts were removed for lab investigations. ISO induced heart injury, ECG disturbance, raise of cardiac troponin I and significant decrease in LVSP (p<0.05), +dp/dt max (p<0.01), -dp/dt max (p<0.05) along with increase of LVEDP (p<0.01). Semelil had no significant effects on ECG and plasma cardiac troponin I. Impairment of +dp/dt max and -dp/dt max was significantly improved in S5+ISO and S10+ISO groups (P<0.05 versus ISO). In addition, LVSP and LVEDP was somewhat recovered in these groups, although semelil (1 mg/kg/day) to some extent exacerbated the myocardial lesions induced by ISO (P<0.05). Therefore, in stressful conditions, semelil may improve myocardial contractility; however, it may aggravate the severity of injury. |
Subject Headings: | arterial blood pressure heart function isoproterenol myocardial injury semelil |
URI: | http://hdl.handle.net/2003/30343 http://dx.doi.org/10.17877/DE290R-5400 |
Issue Date: | 2013-05-23 |
Appears in Collections: | Original Articles |
Files in This Item:
File | Description | Size | Format | |
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Joukar_19022013_proof.pdf | DNB | 1.82 MB | Adobe PDF | View/Open |
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