Authors: Qureshi, Sameera Fatima
Ali, Altaf
Venkateshwari, Ananthapur
Rao, Hygriv
Jayakrishnan, M. P.
Narasimhan, Calambur
Shenthar, Jayaprakash
Thangaraj, Kumarasamy
Nallari, Pratibha
Title: Atrial natriuretic peptide gene - a potential biomarker for Long QT syndrome
Language (ISO): en
Abstract: This study highlights the possible implication of NPPA (natriuretic peptide precursor A) gene in the etiology of Long QT syndrome (LQTS) by population-based as well as familial study. Three SNPs of NPPA- C-664G, C1363A and T1766C were examined by molecular analyses in LQTS, controls and first degree relatives (FDRs). This study revealed a possible association of 1364 C>A SNP ‘C’ allele with LQTS (p = 0.0013). All three SNPs were in tight linkage disequilibrium. The familial study highlights the association of NPPA SNP with cLQTS and implicating it as a potential biomarker in South Indian population.
Subject Headings: atrial natriuretic peptide
Long QT syndrome
cardiogenesis
biomarker
polymorphisms
URI: http://hdl.handle.net/2003/33699
http://dx.doi.org/10.17877/DE290R-6728
Issue Date: 2014-08-15
Appears in Collections:Original Articles

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