|Authors:||Qureshi, Sameera Fatima|
Jayakrishnan, M. P.
|Title:||Atrial natriuretic peptide gene - a potential biomarker for Long QT syndrome|
|Abstract:||This study highlights the possible implication of NPPA (natriuretic peptide precursor A) gene in the etiology of Long QT syndrome (LQTS) by population-based as well as familial study. Three SNPs of NPPA- C-664G, C1363A and T1766C were examined by molecular analyses in LQTS, controls and first degree relatives (FDRs). This study revealed a possible association of 1364 C>A SNP ‘C’ allele with LQTS (p = 0.0013). All three SNPs were in tight linkage disequilibrium. The familial study highlights the association of NPPA SNP with cLQTS and implicating it as a potential biomarker in South Indian population.|
|Subject Headings:||atrial natriuretic peptide|
Long QT syndrome
|Appears in Collections:||Original Articles|
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