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DC Element | Wert | Sprache |
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dc.contributor.author | Hashemi, Mohammad | - |
dc.contributor.author | Sharifi-Mood, Batool | - |
dc.contributor.author | Rasouli, Azam | - |
dc.contributor.author | Amininia, Shadi | - |
dc.contributor.author | Naderi, Mohammad | - |
dc.contributor.author | Taheri, Mohsen | - |
dc.date.accessioned | 2015-04-21T12:39:53Z | - |
dc.date.available | 2015-04-21T12:39:53Z | - |
dc.date.issued | 2015-01-21 | - |
dc.identifier.issn | 1611-2156 | - |
dc.identifier.uri | http://hdl.handle.net/2003/34032 | - |
dc.identifier.uri | http://dx.doi.org/10.17877/DE290R-7597 | - |
dc.description.abstract | Macrophage migration inhibitory factor (MIF) has an important role in controlling infection. The aim of this study was to evaluate the possible association between MIF -173 G/C functional polymorphism and pulmonary tuberculosis (PTB) in an Iranian population from Zahedan Southeast Iran. This case-control study was done on 161 PTB and 142 healthy subjects. Genomic DNA was extracted from all participants by salting out method. The MIF -173 G/C variant was genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The finding showed that the MIF -173 G/C polymorphism increased the risk of PTB in codominant (OR=1.76, 95 % CI=1.05-2.95, p=0.038, GC vs GG) and dominant (OR=1.78, 95 % CI=1.09-2.91, p=0.027, GC+CC vs GG) tested inheritance models. Furthermore, the minor allele frequency (MAF) increased the risk of PTB in comparison with G allele (OR=1.63, 95 % CI=1.07-2.48, p=0.028). In conclusion, the present study provides evidence that -173 G/C polymorphism may increase the risk of PTB. | en |
dc.language.iso | en | - |
dc.relation.ispartofseries | EXCLI Journal ; Vol. 14, 2015 | en |
dc.subject | Tuberculosis | en |
dc.subject | macrophage migration inhibitory factor | en |
dc.subject | MIF | en |
dc.subject | polymorphism | en |
dc.subject.ddc | 610 | - |
dc.title | Macrophage migration inhibitory factor -173 G/C polymorphism is associated with an increased risk of pulmonary tuberculosis in Zahedan, Southeast Iran | en |
dc.type | Text | - |
dc.type.publicationtype | article | - |
dcterms.accessRights | open access | - |
eldorado.dnb.zdberstkatid | 2132560-1 | - |
Enthalten in den Sammlungen: | Original Articles |
Dateien zu dieser Ressource:
Datei | Beschreibung | Größe | Format | |
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Hashemi_21012015_proof.pdf | DNB | 98.58 kB | Adobe PDF | Öffnen/Anzeigen |
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