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dc.contributor.authorDing, Yuling-
dc.contributor.authorWang, Yanmei-
dc.contributor.authorJeon, Byong-Tae-
dc.contributor.authorMoon, Sang-Ho-
dc.contributor.authorLee, Seung-Hong-
dc.date.accessioned2017-10-17T14:14:34Z-
dc.date.available2017-10-17T14:14:34Z-
dc.date.issued2017-03-22-
dc.identifier.issn1611-2156-
dc.identifier.urihttp://hdl.handle.net/2003/36120-
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-18136-
dc.description.abstractThe purpose of the current study was to investigate the potential anti-obesity activity of an enzymatic hydrolysate of velvet antler in inhibiting adipogenesis in 3T3-L1 cells and in high-fat diet (HFD)-fed obese mice. The enzy- matic hydrolysate was prepared using the commercial food grade protease, Protamex. The velvet antler Protamex hydrolysate (VAPH) indicated profound inhibitory effects on adipogenesis dose-dependently by decreasing the accumulation of triglycerides and down-regulating expression levels of adipogenesis-related proteins C/EBPα, SREBP-1, and PPARγ. In a mouse model of HFD-induced obesity, oral administration of VAPH (100 and 300 mg/kg for 13 weeks) significantly reduced the body weight gain that had resulted from the HFD. VAPH treat- ment also lowered the serum glucose and triglyceride levels, while increasing the HDL-C level. Furthermore, the treatment greatly reduced hepatic lipid droplet accumulation as well as the size of adipocytes. Current findings H has profound anti-obesity effects and could be an effective candidate for preventing obesity and obesity-related chronic diseases.en
dc.language.isoen-
dc.relation.ispartofseriesEXCLI Journal;Vol. 16 2017-
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/-
dc.subjectvelvet antleren
dc.subjectenzymatic hydrolysateen
dc.subject3T3- L1 cellsen
dc.subjecthigh-fat dieten
dc.subjectanti-obesity effecten
dc.subject.ddc610-
dc.titleEnzymatic hydrolysate from velvet antler suppresses adipogenesis in 3T3-L1 cells and attenuates obesity in high-fat diet-fed miceen
dc.typeText-
dc.type.publicationtypearticle-
dcterms.accessRightsopen access-
eldorado.dnb.zdberstkatid2132560-1-
eldorado.secondarypublicationtrue-
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