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dc.contributor.authorMahmoudi, Reza-
dc.contributor.authorHonarmand, Zahra-
dc.contributor.authorKarbalay-Doust, Saied-
dc.contributor.authorJafari-Barmak, Mehrzad-
dc.contributor.authorNikseresht, Mohsen-
dc.contributor.authorNoorafshan, Ali-
dc.date.accessioned2017-10-26T13:07:57Z-
dc.date.available2017-10-26T13:07:57Z-
dc.date.issued2017-04-24-
dc.identifier.issn1611-2156-
dc.identifier.urihttp://hdl.handle.net/2003/36150-
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-18166-
dc.description.abstractSodium metabisulfite (Na-MBS) is a disinfectant and preservative agent. Some organ including testicle would be in danger in the case of Na-MBS consumption. Curcumin (CUR) is the constituent of turmeric with protective properties. The effect of CUR on testicles in rats exposed to Na-MBS evaluated using stereological methods. Sprague-Dawley rats were divided into eight groups. The rats in groups I to VIII received the following respec- tively: distilled water, CUR (100 mg/kg/day), low (0.7 mg/kg/day: acceptable daily intake), intermediate (7 mg/ kg/day), and high (70 mg/kg/day) doses of Na-MBS, and low, intermediate, and high doses of Na-MBS plus CUR. After 7 weeks, the testicles were analyzed. The volume of seminiferous tubule, tubular epithelium and tubule length reduced (25-40 %) on average in the rats that received intermediate and high doses of Na-MBS, while the connective tissue volume increased (15-20 %) in both groups (P<0.01). Besides, 19-36 % and 41-57 % of the cells (spermatogonia types A and B, spermatids, Sertoli and Leydig) were lost in the rats that received intermediate and high doses of Na-MBS respectively in comparison to the control groups. Nonetheless, all the above-mentioned alterations ameliorated drastically in the rats that received Na-MBS plus CUR compared to those exposed to Na- MBS without CUR therapy (P<0.01). The acceptable daily intake of Na-MBS for 7 weeks did not affect on testic- ular parameters. CUR (100 mg/kg/day) could prevent structural impairments of testicles in the rats induced by Na-MBS (7 and 70 mg/kg/day).en
dc.language.isoen-
dc.relation.ispartofseriesEXCLI Journal;Vol. 16 2017-
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/-
dc.subjectcurcuminen
dc.subjectraten
dc.subjectsodium metabisulfiteen
dc.subjectstereologyen
dc.subjecttesticleen
dc.subject.ddc610-
dc.titleUsing curcumin to prevent structural impairments of testicles in rats induced by sodium metabisulfiteen
dc.typeText-
dc.type.publicationtypearticle-
dcterms.accessRightsopen access-
eldorado.dnb.zdberstkatid2132560-1-
eldorado.secondarypublicationtrue-
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