Authors: | M’rad, Imen Jeljeli, Mustapha Rihane, Naima Hilber, Pascal Sakly, Mohsen Amara, Salem |
Title: | Aluminium oxide nanoparticles compromise spatial learning and memory performance in rats |
Language (ISO): | en |
Abstract: | Recently, the biosafety and potential influences of nanoparticles on central nervous system have received more attention. In the present study, we assessed the effect of aluminium oxide nanoparticles (Al2O3-NPs) on spatial cognition. Male Wistar rats were intravenously administered Al2O3-NP suspension (20 mg/kg body weight/day) for four consecutive days, after which they were assessed. The results indicated that Al2O3-NPs impaired spatial learning and memory ability. An increment in malondialdehyde levels with a concomitant decrease in superoxide dismutase activity confirmed the induction of oxidative stress in the hippocampus. Additionally, our findings showed that exposure to Al2O3-NPs resulted in decreased acetylcholinesterase activity in the hippocampus. Fur- thermore, Al2O3-NPs enhanced aluminium (Al) accumulation and disrupted mineral element homoeostasis in the hippocampus. However, they did not change the morphology of the hippocampus. Our results show a connection among oxidative stress, disruption of mineral element homoeostasis, and Al accumulation in the hippocampus, which leads to spatial memory deficit in rats treated with Al2O3-NPs. |
Subject Headings: | Aluminium oxide nanoparticle Hippocampus Oxidative response Spatial memory |
URI: | http://hdl.handle.net/2003/36917 http://dx.doi.org/10.17877/DE290R-18916 |
Issue Date: | 2018-02-14 |
Rights link: | https://creativecommons.org/licenses/by/4.0/ |
Appears in Collections: | Original Articles |
Files in This Item:
File | Description | Size | Format | |
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Mrad_14022018_proof.pdf | DNB | 377.94 kB | Adobe PDF | View/Open |
Mrad_supplementary_data_14022018_proof.pdf | DNB | 22.14 kB | Adobe PDF | View/Open |
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