Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Li, Wenbin | - |
dc.contributor.author | Kandhare, Amit D. | - |
dc.contributor.author | Mukherjee, Anwesha A. | - |
dc.contributor.author | Bodhankar, Subhash L. | - |
dc.date.accessioned | 2018-08-22T11:50:11Z | - |
dc.date.available | 2018-08-22T11:50:11Z | - |
dc.date.issued | 2018-05-04 | - |
dc.identifier.issn | 1611-2156 | - |
dc.identifier.uri | http://hdl.handle.net/2003/37104 | - |
dc.identifier.uri | http://dx.doi.org/10.17877/DE290R-19100 | - |
dc.description.abstract | Background: Delayed wound healing is a diverse, multifactorial, complex and inter-related complication of diabetes resulting in significant clinical morbidity. Hesperidin possesses potent antidiabetic and wound healing activity. Aim: To evaluate the potential of hesperidin against experimentally induced diabetes foot ulcers. Methods: Diabetes was induced experimentally by streptozotocin (STZ, 55 mg/kg, i.p.) in Sprague Dawley rats (180-220 g) and wounds were created on the dorsal surface of the hind paw of rats. Hesperidin (25, 50 and 100 mg/kg, p.o.) was administered for 21 days after wound stabilization. Various biochemical, molecular and histopathological parameters were evaluated in wound tissue. Results: STZ-induced decrease in body weight and increase in blood glucose, food, and water intake was significantly (p < 0.05) inhibited by hesperidin (50 and 100 mg/kg) treatment. It showed a significant increase (p < 0.05) in percent wound closure and serum insulin level. The STZ-induced decrease in SOD and GSH level, as well as elevated MDA and NO levels, were significantly (p < 0.05) attenuated by hesperidin (50 and 100 mg/kg) treatment. Intraperitoneal administration of STZ caused significant down-regulation in VEGF-c, Ang-1, Tie-2, TGF-β and Smad 2/3 mRNA expression in wound tissues whereas hesperidin (50 and 100 mg/kg) treatment showed significant up-regulation in these mRNA expressions. STZ-induced alteration in would architecture was also attenuated by hesperidin (50 and 100 mg/kg) treatment. Conclusion: Together, treatment with hesperidin accelerate angiogenesis and vasculogenesis via up-regulation of VEGF-c, Ang-1/Tie-2, TGF-β and Smad-2/3 mRNA expression to enhance wound healing in chronic diabetic foot ulcers. | en |
dc.language.iso | en | - |
dc.relation.ispartofseries | EXCLI Journal;Vol. 17 2018 | - |
dc.relation.replaces | http://hdl.handle.net/2003/37103 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | Diabetic foot ulcer | en |
dc.subject | Hesperidin | en |
dc.subject | VEGF-c | en |
dc.subject | Ang-1 | en |
dc.subject | Tie-2 | en |
dc.subject | TGF-β | en |
dc.subject | Smad 2/3 | en |
dc.subject.ddc | 610 | - |
dc.title | Hesperidin, a plant flavonoid accelerated the cutaneous wound healing in streptozotocin-induced diabetic rats | en |
dc.title.alternative | role of TGF-ß/Smads and Ang-1/Tie-2 signaling pathways | en |
dc.type | Text | - |
dc.type.publicationtype | article | - |
dcterms.accessRights | open access | - |
eldorado.dnb.zdberstkatid | 2132560-1 | - |
eldorado.secondarypublication | true | - |
Appears in Collections: | Original Articles |
Files in This Item:
File | Description | Size | Format | |
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Kandhare_04052018_proof.pdf | DNB | 4.84 MB | Adobe PDF | View/Open |
Kandhare_supplementary_data_04052018.pdf | DNB | 116.16 kB | Adobe PDF | View/Open |
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