Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Klein, Martin | - |
dc.contributor.author | Wegner, Nils | - |
dc.contributor.author | Walther, Frank | - |
dc.contributor.author | Stangier, Dominic | - |
dc.contributor.author | Jung, Ole | - |
dc.contributor.author | Smeets, Ralf | - |
dc.contributor.author | Hartjen, Philip | - |
dc.contributor.author | Schnettler, Reinhard | - |
dc.contributor.author | Feyerabend, Frank | - |
dc.contributor.author | Henningsen, Anders | - |
dc.contributor.author | Rendenbach, Carsten | - |
dc.contributor.author | Heiland, Max | - |
dc.contributor.author | Barbeck, Mike | - |
dc.contributor.author | Kopp, Alexander | - |
dc.date.accessioned | 2019-11-11T15:13:54Z | - |
dc.date.available | 2019-11-11T15:13:54Z | - |
dc.date.issued | 2019-01-10 | - |
dc.identifier.uri | http://hdl.handle.net/2003/38332 | - |
dc.identifier.uri | http://dx.doi.org/10.17877/DE290R-20302 | - |
dc.description.abstract | Magnesium (Mg)-based biomaterials are promising candidates for bone and tissue regeneration. Alloying and surface modifications provide effective strategies for optimizing and tailoring their degradation kinetics. Nevertheless, biocompatibility analyses of Mg-based materials are challenging due to its special degradation mechanism with continuous hydrogen release. In this context, the hydrogen release and the related (micro-) milieu conditions pretend to strictly follow in vitro standards based on ISO 10993-5/-12. Thus, special adaptions for the testing of Mg materials are necessary, which have been described in a previous study from our group. Based on these adaptions, further developments of a test procedure allowing rapid and effective in vitro cytocompatibility analyses of Mg-based materials based on ISO 10993-5/-12 are necessary. The following study introduces a new two-step test scheme for rapid and effective testing of Mg. Specimens with different surface characteristics were produced by means of plasma electrolytic oxidation (PEO) using silicate-based and phosphate-based electrolytes. The test samples were evaluated for corrosion behavior, cytocompatibility and their mechanical and osteogenic properties. Thereby, two PEO ceramics could be identified for further in vivo evaluations. | en |
dc.language.iso | en | de |
dc.relation.ispartofseries | International journal of molecular sciences;Jg. 20, Heft 2. S. 255-1-255-20 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | Magnesium | de |
dc.subject | ISO10993-5/-12 | en |
dc.subject | PEO | en |
dc.subject | Degradation | en |
dc.subject | Biocompatibility | en |
dc.subject | Implant | en |
dc.subject.ddc | 660 | - |
dc.title | Improved in vitro test procedure for full assessment of the cytocompatibility of degradable magnesium based on ISO 10993-5/-12 | en |
dc.type | Text | de |
dc.type.publicationtype | article | de |
dcterms.accessRights | open access | - |
eldorado.secondarypublication | true | de |
eldorado.secondarypublication.primaryidentifier | https://doi.org/10.3390/ijms20020255 | de |
eldorado.secondarypublication.primarycitation | International journal of molecular sciences : Jg.: 20, Heft: 2. S. 255-1-255-20 | de |
Appears in Collections: | Fachgebiet Werkstoffprüftechnik |
Files in This Item:
File | Description | Size | Format | |
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ijms-20-00255-v2.pdf | 5.22 MB | Adobe PDF | View/Open |
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