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dc.contributor.authorCherdtrakulkiat, Rungrot-
dc.contributor.authorLawung, Ratana-
dc.contributor.authorNabu, Sunanta-
dc.contributor.authorTantimavanich, Srisurang-
dc.contributor.authorSinthupoom, Nujarin-
dc.contributor.authorPrachayasittikul, Supaluk-
dc.contributor.authorPrachayasittikul, Virapong-
dc.date.accessioned2020-02-12T13:40:36Z-
dc.date.available2020-02-12T13:40:36Z-
dc.date.issued2019-06-26-
dc.identifier.issn1611-2156-
dc.identifier.urihttp://hdl.handle.net/2003/38567-
dc.identifier.urihttp://dx.doi.org/10.17877/DE290R-20486-
dc.description.abstractAntimicrobial resistance has become a prime global concern. An ability of the microbes to produce enzymes to destroy antimicrobial drugs is one of the well-known mechanisms underlying the resistance. 8-Hydroxyquinoline (8HQ) and derivatives were reported to exert diverse biological effects such as antimicrobial, antioxidant and an- tineurodegenerative activities. Herein, 8HQ (1), nitroxoline (NQ, 2) and 7-Br-8HQ (3) were investigated for antimicrobial activity against Enterobacteriaceae including extended spectrum β-lactamase (ESBL)-producing and carbapenemase-producing strains as well as the effect of metal ions .These compounds (1-3) displayed the great antimicrobial activity against fifty-eight bacterial isolates of Escherichia coli, Providencia rettgeri and Klebsiella pneumoniae, in which NQ (2) exerted the highest antimicrobial activity with a MIC50 of 42.04 ❍M (8 µg/mL) and MBC50 of 168.28 ❍M (32 µg/mL). The MIC values of NQ (2) and 7-Br-8HQ (3) were significantly increased in the presence of Cu2+ and Fe3+. This finding reveals that NQ could be an effective compound to be further developed as an antimicrobial agent for combating Enterobacteriaceae infections.en
dc.language.isoen-
dc.relation.ispartofseriesEXCLI Journal;Vol. 18. 2019-
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/-
dc.subjectEnterobacteriaceaeen
dc.subjectMultidrug resistanceen
dc.subjectAntimicrobial activityen
dc.subject8-hydroxyquinolineen
dc.subjectNitroxolineen
dc.subject.ddc610-
dc.titleNitroxolineen
dc.title.alternativea potent antimicrobial agent against multidrug resistant Enterobacteriaceaeen
dc.typeText-
dc.type.publicationtypearticle-
dcterms.accessRightsopen access-
eldorado.dnb.zdberstkatid2132560-1-
eldorado.secondarypublicationtrue-
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