Autor(en): | Enko, Dietmar Zelzer, Sieglinde Wenninger, Julian Holasek, Sandra Schnedl, Wolfgang J. Baranyi, Andreas Herrmann, Markus Meinitzer, Andreas |
Titel: | Interleukin-6 is associated with tryptophan metabolism and signs of depression in individuals with carbohydrate malabsorption |
Sprache (ISO): | en |
Zusammenfassung: | The aim of the present study was to investigate possible associations between interleukin-6 (IL-6), interferon-gamma (INF-γ), tumor necrosis factor-alpha (TNF-α), lactoferrin and lipopolysaccharide binding protein (LBP) with TRP metabolism and signs of depression in a large cohort of outpatients referred for carbohydrate malabsorption testing. Serum concentrations of IL-6, INF-γ, TNF-α, lactoferrin, LBP, tryptophan (TRP), kynurenine (KYN) and kynuric acid were determined in 250 adults referred for lactose and fructose malabsorption testing. All participants filled out the Beck Depression Inventory (BDI). Serum IL-6 levels were positively correlated with the BDI score (p = 0.001, ρ = 0.205) and indicators of TRP metabolism (KYN/TRP ratio, KYN) (P-values < 0.05, ρ = 0.176 and 0.136). Ninety-five individuals with a BDI score > 13 showed significantly higher IL-6 serum levels (1.7 [1.0 – 2.8] vs. 1.1 [0.8 – 1.7] pg/mL, p < 0.001) compared to 115 individuals with a BDI score ≤ 13. LBP showed a positive correlation with the KYN/TRP ratio (p = 0.005, ρ = 0.177). IL-6 and LBP were associated with indicators of TRP metabolism. IL-6 was found to be linked to signs of depression. Individuals with the presence of depressive symptoms showed higher serum IL-6 levels compared to individuals without depressive symptoms. |
Schlagwörter: | Depression Inflammation Interleukin-6 Interferon-gamma Tumor necrosis factor-alpha Lactoferrin |
URI: | http://hdl.handle.net/2003/39899 http://dx.doi.org/10.17877/DE290R-21789 |
Herausgeberlink: | https://www.excli.de/index.php/excli/article/view/2940 |
Erscheinungsdatum: | 2020-10-28 |
Rechte (Link): | https://creativecommons.org/licenses/by/4.0/ |
Provinienz: | IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund |
Zitierform: | Enko, D., Zelzer, S., Wenninger, J., Holasek, S., Schnedl, W. J., Baranyi, A., Herrmann, M., & Meinitzer, A. (2020). Interleukin-6 is associated with tryptophan metabolism and signs of depression in individuals with carbohydrate malabsorption. EXCLI Journal, 19, 1414-1422. https://doi.org/10.17179/excli2020-2940 |
Enthalten in den Sammlungen: | Original Articles 2020 |
Dateien zu dieser Ressource:
Datei | Beschreibung | Größe | Format | |
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excli2020-2940.pdf | DNB | 254.17 kB | Adobe PDF | Öffnen/Anzeigen |
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