Authors: | Dahms, S. Kunert, J. Voss, B. Weiss, H. |
Title: | A Multinomial Model for the Quality Control of Colony Counting Procedures |
Language (ISO): | en |
Abstract: | The so-called good-laboratory-practice (GLP) test provides an experimental design and appropriate statistical analysis for the problem of analyst performance assessment in microbiological laboratories. For a given sample material multiple dilution series are generated yielding colony counts from several dilution levels. Statistical evaluation is based on the assumption of Poisson-distributed colony forming units. In this paper a new model based on conditional binomial and multinomial distributions is presented and it is shown how it is related to the standard model which assumes Poisson-distributed colony counts. The effects of common working errors on the statistical evaluation of the GLP-test are investigated. |
Subject Headings: | good-laboratory-practice-test multinomial model Poisson model quality control standardized analytical methods |
URI: | http://hdl.handle.net/2003/4955 http://dx.doi.org/10.17877/DE290R-6644 |
Issue Date: | 1999 |
Provenance: | Universitätsbibliothek Dortmund |
Appears in Collections: | Sonderforschungsbereich (SFB) 475 |
Files in This Item:
File | Description | Size | Format | |
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99_19.pdf | DNB | 320.41 kB | Adobe PDF | View/Open |
tr19-99.ps | 5.71 MB | Postscript | View/Open |
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