Authors: Dahms, S.
Kunert, J.
Voss, B.
Weiss, H.
Title: A Multinomial Model for the Quality Control of Colony Counting Procedures
Language (ISO): en
Abstract: The so-called good-laboratory-practice (GLP) test provides an experimental design and appropriate statistical analysis for the problem of analyst performance assessment in microbiological laboratories. For a given sample material multiple dilution series are generated yielding colony counts from several dilution levels. Statistical evaluation is based on the assumption of Poisson-distributed colony forming units. In this paper a new model based on conditional binomial and multinomial distributions is presented and it is shown how it is related to the standard model which assumes Poisson-distributed colony counts. The effects of common working errors on the statistical evaluation of the GLP-test are investigated.
Subject Headings: good-laboratory-practice-test
multinomial model
Poisson model
quality control
standardized analytical methods
Issue Date: 1999
Provenance: Universitätsbibliothek Dortmund
Appears in Collections:Sonderforschungsbereich (SFB) 475

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