Experimental and numerical characterization of screw elements used in twin-screw extrusion

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dc.contributor.authorDüphans, Vanessa
dc.contributor.authorKimmel, Vincent
dc.contributor.authorMessing, Lukas
dc.contributor.authorSchaldach, Gerhard
dc.contributor.authorThommes, Markus
dc.date.accessioned2025-08-21T12:46:30Z
dc.date.available2025-08-21T12:46:30Z
dc.date.issued2024-07-16
dc.description.abstractHot melt extrusion by a co-rotating twin screw extruder is an important process in the pharmaceutical industry. Especially for quality by design aspects, a comprehensive process understanding is indispensable. The performance of conveying elements was determined as critical process parameter, and therefore an experimental and numerical framework was developed to analyze and compare variations. A test rig capable of measuring volume flow, pressure and torque with high accuracy and precision was designed and built. The 3D simulation was performed using computational fluid dynamics (CFD). A stationary model with impulse transmission and an apparent motion of the screws was applied. The experimental data were fitted to the model of Pawlowski, and parameters for the pressure (A1, A2) and power characteristics (B1, B2) were determined. Good agreement between experimental data and the model was observed. The simulation was significantly faster compared to common methods, and the results were consistent with the literature. Systematic investigations of a native and worn screw were performed with CFD resulting in a transport capacity increase and a pressure build up decrease for all tested screw elements. An experimental and simulation setup was generated to assess the performance of co-rotating twin screw elements. The experiments provided high-quality data, and the simulations exhibited high flexibility with low computational effort.en
dc.identifier.urihttp://hdl.handle.net/2003/43861
dc.language.isoen
dc.relation.ispartofseriesPharmaceutical development and technology; 29(7)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectExtrusionen
dc.subjectModelingen
dc.subjectViscosityen
dc.subjectScrewen
dc.subjectExperimentsen
dc.subjectComputational fluid dynamicsen
dc.subject.ddc660
dc.titleExperimental and numerical characterization of screw elements used in twin-screw extrusionen
dc.typeText
dc.type.publicationtypeResearchArticle
dcterms.accessRightsopen access
eldorado.doi.registerfalse
eldorado.secondarypublicationtrue
eldorado.secondarypublication.primarycitationDüphans, V., Kimmel, V., Messing, L., Schaldach, G., & Thommes, M. (2024). Experimental and numerical characterization of screw elements used in twin-screw extrusion. Pharmaceutical Development and Technology, 29(7), 675–683. https://doi.org/10.1080/10837450.2024.2378323
eldorado.secondarypublication.primaryidentifierhttps://doi.org/10.1080/10837450.2024.2378323

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