Zarei, FarzanehMenbari, Mohammad NazirGhaderi, BayazidAbdi, MohammadVahabzadeh, Zakaria2018-02-052018-02-052017-11-061611-2156http://hdl.handle.net/2003/3635410.17877/DE290R-18355There is an increasing interest about studying possible effects of genetic polymorphisms and risk of cancer pro- gression. E-cadherin (CDH1) involves in many important cellular processes including cell-cell interactions, cell development and genetic changes of this molecule has been associated with greater tumor metastasis. The present study was aimed to evaluate the possible role of CDH1 -160 C/A polymorphism as a potential risk factor for breast cancer in Kurdish population. This case-control study consisted of 100 breast cancer patients and 200 healthy controls. Clinicopathological findings of all individuals were reported and immunohistochemistry staining was carried out on tissue samples. The CDH1 -160 C/A genotype was determined by polymerase chain reaction- re- striction fragment length polymorphism method (PCR-RFLP). CDH1 -160 C/A polymorphism was differently distributed between patient and control groups. The A allele of CDH1 -160 C/A polymorphism significantly in- creased in patients compared to controls. In addition we found that the A allele of this polymorphism might be a potential risk factor for progression of breast cancer in our studied population. Patients with A allele of CDH1 -160 C/A was in higher risk to progress invasive ductal carcinoma. The A allele was also correlated with high grade and stage IV and also with metastatic tumors in studied subjects. The CDH1 -160 C/A polymorphism is correlated with clinicopathologial findings of breast cancer patients. The A allele of CDH1 -160 C/A may be a risk factor for progression of breast cancer in Kurdish patients.enEXCLI Journal;Vol. 16 2017http://creativecommons.org/licenses/by/4.0/Breast cancerCDH1MetastasisPolymorphismPrognosis610article (journal)