Doungsoongnuen, SutanunPingaew, RatchanokPrachayasittikul, SupalukPrachayasittikul, VirapongRuchirawat, SomsakSuksrichavalit, ThummarukWorachartcheewan, Apilak2011-12-022011-12-022011-12-02http://hdl.handle.net/2003/2920310.17877/DE290R-3249In the previous studies, the cytotoxicities of anthranilate sulfonamides were investigated. Herein, the bioactivities of 4-substituted (X = NO2, OCH3, CH3, Cl) benzenesulfonamides of anthranilic acid (5-8) are reported. The results revealed that all sulfonamides selectively exerted antifungal activity (25-50 % inhibition) against C. albicans at 4 μg/mL. Furthermore, compounds 6 and 8 show antioxidative (SOD) activity. These sulfonamides, except for 6, selectively display cytotoxic effects toward MOLT-3 cells. It is interesting to note that sulfonamides with electron withdrawing substituent (5, X = NO2) exhibited the highest cytotoxicity. This study provided preliminary structure-activity relationship of the anthranilic sulfonamides that is useful for further in-depth investigation.enEXCLI Journal ; Vol. 10, 2011anthranilic acidantimicrobialsantioxidantscytotoxicitysulfonamides610article (journal)