Winker, MatteoStössel, SandraNeu, Marie AstridLehmann, NadineEl Malki, KhalifaParet, ClaudiaJoisten, NiklasBloch, WilhelmZimmer, PhilippFaber, Jörg2022-05-112022-05-112021-12-03http://hdl.handle.net/2003/4090010.17877/DE290R-22756While exercise and physical activity have been suggested to reduce mortality and symptoms in cancer, knowledge on these associations in patients with childhood cancer (CCPs) is sparse. Anti-inflammatory properties of exercise might mediate these beneficial effects. We investigated the influence of exercise on the inflammation markers neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and systemic-immune-inflammation index (SII) and associations to patient-reported-outcomes in CCPs in a randomized-controlled trial. Results show associations between inflammation markers and patient-reported outcomes. Compared to the control group, SII was significantly reduced following exercise (p=0.036). Anti-inflammatory effects of exercise are also present in CCPs and may underlie exercise-induced benefits on symptoms. Clinical Trial Registration Number: NCT02612025enSupportive care in cancer;Bd 30. 2021, Heft 4, S. 2905-2908http://creativecommons.org/licenses/by/4.0/http://creativecommons.org/licenses/by/4.0/Tumor entitiesCellular inflammationPediatric oncologyResistance trainingEndurance training796article (journal)KindOnkologieSport