Fluorescence microscopy studies on the fibrillation of IAPP at model and cellular lipid interfaces, from mechanism to potential strategies in type II diabetes mellitus

Radovan, Diana2009-10-212009-10-212009-10-21http://hdl.handle.net/2003/2646310.17877/DE290R-15340enIslet amyloid polypeptide (IAPP)AmyloidType II diabetes mellitusFibril formationProtein aggregationIAPP fragmentsGiant unilamellar vesicles (GUVs)Raft membrane model systemsINS-1E cell lineResveratrolAdvanced fluorescence microscopyConfocal, two-photon excitationHigh hydrostatic pressure (HHP)FT-IR spectroscopyAtomic force microscopy (AFM)CytotoxicityWST-1 assay540Fluorescence microscopy studies on the fibrillation of IAPP at model and cellular lipid interfaces, from mechanism to potential strategies in type II diabetes mellitusdoctoral thesisurn:nbn:de:hbz:290-2003/26463-2