Sarapukdee, PongsakSpenner, ChristianSchulz, DirkPalzer, Stefan2023-08-022023-08-022023-07-28http://hdl.handle.net/2003/4204510.17877/DE290R-23878The use of surface plasmon resonance sensors allows for the fabrication of highly sensitive, label-free analytical devices. This contribution reports on a grating coupler to enable surface plasmon resonance studies using silver on silicon oxide technology to build long-term stable plasmonic structures for biological molecule sensing. The structural parameters were simulated and the corresponding simulation model was optimized based on the experimental results to improve its reliability. Based on the model, optimized grating nanostructures were fabricated on an oxidized silicon wafer with different structural parameters and characterized using a dedicated optical setup and scanning electron microscopy. The combined theoretical and experimental results show that the most relevant refractive index range for biological samples from 1.32–1.46 may conveniently be covered with a highest sensitivity of 128.85°/RIU.enSensors;Vol. 23. 2023, 15, Art. No 6743https://creativecommons.org/licenses/by/4.0/Plasmon resonanceMicrofabricationGrating couplerSimulation modelLabel-freeProtective layerBiosensorsSilverRefractive index620Article