Hartung, Joachim2004-12-062004-12-062000http://hdl.handle.net/2003/501710.17877/DE290R-15038A class of self-designing clinical trials is considered which according to an effective but simple, finite learning algorithm consists of automatically adaptively planned weighted group sequential trials with a decision about rejection of the null-hypothesis at each step, but the full level- a-test at the end of the study preserved.enUniversitätsbibliothek Dortmund310report