Lawung, RatanaCherdtrakulkiat, RungrotNabu, SunantaPrachayasittikul, SupalukIsarankura-Na-Ayudhya, ChartchalermPrachayasittikul, Virapong2019-02-012019-02-012018-08-231611-2156http://hdl.handle.net/2003/3789610.17877/DE290R-19883The multidrug resistance of Neisseria gonorrhoeae becomes a public health problem worldwide, especially the strain H041 that showed the decrease susceptibility to ceftriaxone which is the last resort for gonorrhea treat- ment. Therefore, the simultaneous discovery and development of a new compound to fight this pathogen is ur- gently required. In this study, 8-hydroxyquinoline (8HQ) and derivatives were evaluated for their antimicrobial activities against the gonococcal pathogen using spectinomycin as the reference drug. The results showed that 8HQ derivatives gave an excellent antimicrobial potency. Particularly, the dihalogenated 8HQ (iodoquinol, clio- quinol and 5,7-diCl-8HQ) exerted the high activity with MIC range of 0.08-0.15 µM, 0.10-0.20 µM and 0.28- 0.56 µM, respectively, compared with the reference drug (MIC = 16 µg/mL or 48.14 µM). Moreover, these compounds were also shown to be non-cytotoxic/very high safety index. The findings reveal that these three compounds could be further developed as a new antimicrobial agent for fighting the gonorrheal disease.enEXCLI Journal;Vol. 17 2018https://creativecommons.org/licenses/by/4.0/Neisseria gonorrhoeaeAntimicrobial resistanceAntibacterial activity8-hydroxyquinoline and derivatives610article (journal)