Bobers, JensHahn, Lisa KatharinaAverbeck, TobiasBrunschweiger, AndreasKockmann, Norbert2024-03-012024-03-012022-03-11http://hdl.handle.net/2003/4236910.17877/DE290R-24206The combination of lab automation and design of experiments for the execution of screening experiments increases productivity and reduces error-prone manual work. A self-developed software tool allows for creating fractional-factorial experimental design (FFED). Application of FFED on the screening of a Suzuki-Miyaura cross-coupling leads to a 93 % reduced design compared to full-factorial design. The resulting regression model qualitatively shows the positive effect of educt concentrations, time, and temperature and reveals the decrease in conversion at high base concentrations.enChemie - Ingenieur - Technik;94(5)https://creativecommons.org/licenses/by/4.0/Design of experimentsLab automationReaction optimizationSuzuki-Miyaura reaction660ArticleVersuchsplanungLabortechnikAutomationReaktionsoptimierungSuzuki-Miyaura-Reaktion