Qureshi, Sameera FatimaAli, AltafVenkateshwari, AnanthapurRao, HygrivJayakrishnan, M. P.Narasimhan, CalamburShenthar, JayaprakashThangaraj, KumarasamyNallari, Pratibha2014-11-252014-11-252014-08-151611-2156http://hdl.handle.net/2003/3369910.17877/DE290R-6728This study highlights the possible implication of NPPA (natriuretic peptide precursor A) gene in the etiology of Long QT syndrome (LQTS) by population-based as well as familial study. Three SNPs of NPPA- C-664G, C1363A and T1766C were examined by molecular analyses in LQTS, controls and first degree relatives (FDRs). This study revealed a possible association of 1364 C>A SNP ‘C’ allele with LQTS (p = 0.0013). All three SNPs were in tight linkage disequilibrium. The familial study highlights the association of NPPA SNP with cLQTS and implicating it as a potential biomarker in South Indian population.enEXCLI Journal ; Vol. 13, 2014atrial natriuretic peptideLong QT syndromecardiogenesisbiomarkerpolymorphisms610article (journal)