Jankowski, NicholasDietrich, JulianKrause, Norbert2024-01-222024-01-222022-08-08http://hdl.handle.net/2003/4229210.17877/DE290R-24128A transition metal-free method for the cycloisomerization of propargylic amides to oxazoles was developed. The reaction utilizes in situ generated hydrogen chloride in hexafluoroisopropanol (HFIP). With the aid of Design of Experiments optimization a wide range of substrates was transformed into the desired oxazoles. The method allows product formation without side reactions eliminating the need for extensive work-up and purification.enAdvanced synthesis & catalysis;364(19)https://creativecommons.org/licenses/by-nc-nd/4.0/Brønsted acid catalysisCycloisomerizationDesign of ExperimentsSolvent effectsTransition metal-free synthesis540ResearchArticle