Schmalenberg, MiraWeick, Lena K.Kockmann, Norbert2021-04-062021-04-062021-03-24http://hdl.handle.net/2003/4013610.17877/DE290R-22011Nucleation in continuously operated capillary coiled cooling crystallizers is experimentally investigated under the influence of ultrasound. It was found that there is no sharp boundary but rather a transition zone for nucleation under sonication. For this purpose, a tube with an inner diameter of 1.6 mm and a length of 6 m was winded in a coiled flow inverter (CFI) design and immersed into a cooled ultrasonic bath (37 kHz). The CFI design was chosen for improved radial mixing and narrow residence time distribution, which is also investigated. Amino acid l-alanine dissolved in deionized water is employed in a supersaturation range of 1.10 to 1.46 under quiet and sonicated conditions. Nucleation is non-invasive detected using a flow cell equipped with a microscope and camera.enJ Flow Chem;https://creativecommons.org/licenses/by/4.0/Coiled flow inverterContinuous nucleationCooling crystallizationMinichannelCapillary flowNon-invasive nucleation detectionSonocrystallization660article (journal)WechselrichterKühlungskristallisationKapillarströmung