Muñoz‐López, AlvaroJung, AnneBuchmuller, BenjaminWolffgramm, JanMaurer, SaraWitte, AnnaSummerer, Daniel2021-05-272021-05-272020-09-20http://hdl.handle.net/2003/4020510.17877/DE290R-22078Two‐TALE test: Engineered transcription‐activator‐like effector (TALE) repeats can be used to design programmable receptors for improved in situ imaging‐based analysis of 5 mC in user‐defined DNA sequences. Pairs of natural 5 mC‐discriminating and engineered 5 mC‐binding TALEs allow nucleotide resolution analysis of 5 mC with response of both TALEs. This provides an impulse for the design of programmable imaging probes for studying 5 mC functions in chromatin regulation with increased dynamic range.enChemBioChem;Vol. 22. 2021, Issue 4, pp 645-651https://creativecommons.org/licenses/by/4.0/DNA methylationEpigeneticsImaging probesMembrane-less organelles570540article (journal)