Kriegler, SimonJaworek, Michel W.Oliva, RosarioWinter, Roland2024-07-082024-07-082023-03-29http://hdl.handle.net/2003/42587http://dx.doi.org/10.17877/DE290R-24422The helical structure that cationic antimicrobial peptides (cAMPs) adopt upon interaction with membranes is key to their activity. We show that a high hydrostatic pressure not only increases the propensity of cAMPs to adopt a helical conformation in the presence of bacterial lipid bilayer membranes, but also in bulk solution, and the effect on bacterial membranes persists even up to 10 kbar. Therefore, high-pressure treatment could boost cAMP activity in high-pressure food processing to extend the shelf-life of food.en540Text