Aikawa, JúliaBonatto, Sandro José RibeiroFreire dos Santos, LeandroHabu, SaschaPrado, Karin BraunRubel, RosáliaSoccol, Carlos RicardoSoccol, Vanete ThomazTorres, Maria FernandaYamaguchi, Adriana AyaZanatta, Ana Lucia2013-05-132013-05-132013-05-131611-2156http://hdl.handle.net/2003/3031410.17877/DE290R-10558This study investigated the effect of Cordyceps sinensis biomass supplementation obtained from submerged fermentation on blood lipid and low testosterone induced by high-fat diet (HFD). The experiments were carried out using a long-term intake of HFD and HFD plus Simvastatin or C. sinensis (4 months). Our results show that plasma cholesterol, triglycerides and LDL were decreased by Cordyceps sinensis biomass supplementation (CSBS). A longterm intake of HFD caused a significant liver damage which has been reverted by CSBS. CSBS normalized decreasing testosterone levels observed in high-fat diet feed rats. All these findings lead us to suggest that C. sinensis was able to decrease blood lipid concentration, increase hepatoprotective activity and normalize testosterone levels.enEXCLI Journal ; Vol. 11, 2012Cordyceps sinensishigh-fat diethypolipidemic effecttestosterone610article (journal)