Students’ math-related expectancies of success and subjective task values are important predictors of their educational and career choices, such as students’ decisions to persist in or drop out of math-intensive study programs in the fields of science, technology, engineering, and mathematics (STEM). Introductory math courses are often a gatekeeper to further engagement and success in STEM fields because students often experience low levels of motivation and achievement in such courses. Howev...

Time series arise in a variety of application domains—whenever data points are recorded over time and stored for subsequent analysis. A critical question is whether the occurrence of events like natural disasters, technical faults, or political interventions leads to changes in a time series, for example, temporary deviations from its typical behavior. The vast majority of existing research on this topic focuses on the specific impact of a single event on a time series, while methods to gener...

Die Kombination von molekularbiologischen Methoden, wie der genetischen Kodierung, Selektion, DNA-Amplifikation und DNA-Sequenzierung, mit der kombinatorischen organischen Chemie konnte große Sammlungen an Molekülen, sogenannte DNA-kodierte Bibliotheken, für die Identifikation von bioaktiven Molekülen ermöglichen. Dabei besteht eine große Herausforderung in der nur geringen Abdeckung des chemischen Raumes durch die notwendige Kompatibilität der verwendeten organischen Reaktionen mit dem DNA-B...

Protein arginine methyltransferase 5 (PRMT5) is an important enzyme, methylating arginine residues of its substrates. PRMT5 is involved in a very large number of various cellular process, and has strong ties to a plethora of health disorders. PRMT5 mediates a number of protein-protein interactions (PPIs) with diverse adaptor proteins, such as the obligate binding partner MEP50, and adaptor proteins RioK1, pICln and COPR5. Modulation of PRMT5 PPIs appears as an attractive alternative to the in...

This dissertation consists of four independently written essays dealing with inference and prediction of financial data sets. The first part of this dissertation focuses on the inference element and contains two chapters that explore the question of how financial markets priced companies’ stocks during the market collapse caused by the COVID-19 pandemic in the beginning of 2020. As the COVID-19 pandemic and the subsequent economic lockdown represented one of the most impacting exogenous shock...

Die vorliegende Arbeit ist eine qualitative empirische Untersuchung zur Relevanz textiler Praktiken bei der Identitätsbildung jugendlicher Geflohener. Es wird beleuchtet, inwieweit Mode und textile Handlungen eine identitätsstiftende Funktion haben und auf welche Weise sich dies konkret in der vestimentären Praktik zeigt. Der Fokus lag auf dem Wandel, der sich in der neuen Lebenswelt mit Blick auf die Körper- und Kleidungsideale vollzieht. Die Untersuchung stützt sich auf Befragungen und Beo...

Der Forschungsverbund DJI/TU Dortmund liefert den ersten landesspezifischen Bericht zur Kindertagesbetreuung in Nordrhein-Westfalen. Der indikatorenbasierte Bericht umfasst rund 130 Seiten und berichtet grundlegende Kennzahlen zum System der Kindertagesbetreuung in Nordrhein-Westfalen. Entwicklungen aus den Bereichen der Angebotsstrukturen, der Betreuungs- und Versorgungssituation sowie des tätigen Personals im System der Kindertagesbetreuung werden aus unterschiedlichen Perspektiven beleucht...

Im ersten Teil dieser Arbeit wird ein neu installierter Aufbau beschrieben, der die gleichzeitige Durchführung optischer und magneto-optischer Pump-Probe Experimente als Funktion der Temperatur, eines Magnetfeldes oder eines angelegten elektrischen Feldes ermöglicht. Im zweiten Teil dieser Arbeit wird mit optischen Anregungen untersucht, ob eine Kopplung zwischen dem Spinsystem und dem elektronischen System in dem magnetischen Halbleiter α-MnTe existiert. Dazu wird eine 200 nm dicke Schicht α...

Metastasis remains a major problem for tumor therapy. In endometrial and ovarian cancer, metastasis and worse survival was found to be associated with elevated EDI3 (GPCPD1; GDE5; GDPD6) expression in primary tumors. EDI3 is a glycerophosphodiesterase which cleaves glycerophosphocholine (GPC) to form choline and glycerol-3-phosphate (G3P) and is therefore considered one of the key enzymes involved in choline metabolism. Altered choline metabolism is a recognized metabolic hallmark of cancer a...

This work deals with certain components of an automated driving system for highways, focusing on lane change behavior planning. It presents a variety of algorithms of a modular system aiming at safe and comfortable driving. A major contribution of this work is a method for analyzing traffic scenes in a spatio-temporal, curvilinear coordinate system. The results of this analysis are used in a further step to generate lane change trajectories. A total of three approaches with increasing ...

Spectroscopic measurements are an indispensable tool in chemical analysis; even under extreme conditions such as high hydrostatic pressures, they can provide valuable insights. Theoretical methods that can reliably reproduce observables in solution can be used to validate the obtained results. A common theoretical model is the Reference Interaction Site Model (RISM), which was used in this work. In the first part, a previously developed method for calculating IR frequencies with the embedded ...

This dissertation focuses on the development, formalization, and systematic evaluation of a novel nonlinear model predictive control (MPC) concept with derivative-free optimization. Motivated by a real industrial application, namely the position control of a directional control valve, this control concept enables straightforward implementation from scratch, robust numerical optimization with a deterministic upper computation time bound, intuitive controller design, and offers extensions ...

Renewable energy sources (RES) are gradually penetrating power systems through power electronic converters (PECs), which greatly change the structure and operation characteristics of traditional power systems. The maturation of PECs has also laid a technical foundation for the development of DC microgrids (DC-MGs). The advantages of DC-MGs over AC systems make them an important access target for RES. Due to the multi-timescale characteristics and fast response of power electronics, the dynami...

In the ongoing and aggravating global climate crisis, the effects of ecological disruption on firms, investors, and society as a whole are being increasingly investigated in the literature. Physical risks, such as increasing average temperatures or rising sea levels, are believed to be the top climate-related risk factor for investors over a time horizon of 30 years and motivate the currently increasing demand for green assets. However, the empirical literature is divided on how green assets ...

Wie wichtig in der digitalen Wissenschaft die dauerhafte, eindeutige Zuordnung wissenschaftlicher Publikationen zu ihren Autorinnen und Autoren ist, beschreibt Höhner in ihrem Artikel über den internationalen Standard Open Researcher and Contributor ID, der sogenannten ORCID iD. Sie stellt die Idee der Nonprofit-Organisation, die Funktionsweise sowie die Vorteile des ORCID Records für die Wissenschaftlerinnen und Wissenschaftler, deren Forschungseinrichtungen und Forschungsförderern vor. Absc...