With the global trend towards automated driving, fault-tolerant onboard power supply systems are introduced into modern vehicles and the level of driving automation is continuously increasing. These advancements contribute to the applicability of Steer-by-Wire systems and the development of automated lateral vehicle guidance control functions. For the market acceptance of automated driving, the lateral vehicle guidance control function must hereby be cooperative, that is it must accept driver...

Die NMR-Spektroskopie, als eine der vielfältigsten Methoden der Analytik, hilft dabei Probleme von chemischem Interesse zu lösen und das Verständnis zu erweitern. Diese Arbeit beschäftigt sich mit der Untersuchung der chemischen und physikalischen Eigenschaften von Polymeren mittels NMR-Spektroskopie unter Verwendung bekannter Methoden sowie neu entwickelter Applikationen. Besonderer Fokus liegt dabei auf der Diffusion Ordered Spectroscopy (DOSY). Für die Untersuchung von mizellaren Systemen ...

With the discovery of the astrophysical neutrino flux by IceCube in 2013, the foundation for neutrino astronomy was established. In subsequent years, the first point-like neutrino source candidates, a flaring blazar known as TXS 0506+056 and the active galaxy NGC 1068, emerged. Now, in this work, a new milestone in the rising field of neutrino astronomy is presented: the first observation of high-energy neutrinos from our own Galaxy — the Milky Way. A search for Galactic neutrino emission is ...

Abstract for the PHD Thesis Transfer Learning for Multi-Channel Time-Series Human Activity Recognition Methods of human activity recognition (HAR) have been developed for the purpose of automatically classifying recordings of human movements into a set of activities. Capturing, evaluating, and analysing sequential data to recognise human activities accurately is critical for many applications in pervasive and ubiquitous computing applications, e.g., in applications such as mobile- or a...

There has been considerable interest in recent years in “intensified processes” that allow for the substantial amelioration of chemical processes in terms of equipment dimensions, costs, and safety. The integration of an additional separative functionality into chemical reactors can be used to manipulate the concentration and temperature profiles and thus dramatically enhance reactor performance. The resultant improvements in conversion and selectivity can, in turn, simplify or even eliminate...

Continuous technological advancements in the field of grinding technology and improved grinding tools have contributed to the development of high performance grinding processes. One example of such a process is internal traverse grinding (ITG) with electroplated cBN grinding wheels, where the tool consists of a conical roughing zone and a cylindrical finishing zone. Since the tool is fed in axial direction into a revolving workpiece, spindle deflections induced by varying process forces can l...

The nature of acceleration processes of very-high-energy radiation in the universe is largely unsolved. To study these, Imaging Atmospheric Cherenkov Telescopes measure Cherenkov radiation produced by secondary particles in Extensive Air Showers. The Cherenkov Telescope Array (CTA) is the next generation of ground-based Cherenkov astronomy to be built in the coming years parts on La Palma, Spain and parts at Paranal Observatory, Chile. The first prototype telescope of CTA, the LST-1, was inau...

Flexibility of the polypeptide chains plays the key role in protein functions, their un-, re- and misfolding pathways. Understanding the conformational landscape which protein chain occupies statically and dynamically is essential for understanding of cellular processes and ultimately, designing efficient drugs, safe pesticides, and industrial biotechnological processes. NMR spectroscopy is an indispensable technique studying disordered molecules site-specifically, both in solution and in the...

Das Ziel dieser Arbeit war es, Si-stereogene Organosilane über substratinduzierte diastereoselektive Synthesen mit hohen Diastereomerenüberschüssen zu erzeugen, und die Reaktionen stereochemisch zu untersuchen. Im direkten Anschluss erfolgte die intensive Untersuchung des stereochemischen Ver¬laufs der Substitution der verbliebenen funktionellen Gruppen. Nach Synthese der Si-stereogenen Silane erfolgte die konfigurelle Aufklärung über die Co-Kristallisation mit der Halogenbrücken-Methode als ...

Die Arbeit gliedert sich in vier Themenblöcke aus der Übergangsmetallkoordinationschemie mit synthetisierten Silyl-substituierten Thioether-Liganden. Dabei standen die Kupfer(I)-halo¬ge¬nide im Fokus. Im ersten Teil konnte mit 1,3-Dithian-substituierten Liganden eine Vielzahl von molekularen und polymeren Komplexen synthetisiert und strukturell aufgeklärt werden. Sowohl monometallische Komplexe der Kupfer(I)-halogenide als auch bimetallische Komplexe, bestehend aus den Halogeniden der Zinkgr...

Dies ist das ergänzende R-Skript zum Manuskript/ Buch mit dem Titel: "Eine praktische Einführung in die Statistik mit R und RStudio - Ein Lehrskript für Studierende der Rehabilitationspädagogik, Rehabilitationswissenschaften sowie (Sonder-)Pädagogik" von Christian Kißler, Florian Krieger und Jörg-Tobias Kuhn.

The ever-growing complexity of today’s software and hardware systems makes quality assurance (QA) a challenging task. Abstraction is a key technique for dealing with this complexity because it allows one to skip non-essential properties of a system and focus on the important ones. Crucial for the success of this approach is the availability of adequate abstraction models that strike a fine balance between simplicity and expressiveness. This thesis presents the formalisms of systems of proced...

Cell-cell fusion is essential for sexual reproduction and occurs when the lipid membranes of two distinct cells merge into one continuous bilayer. While in recent years some general aspects have been uncovered, the underlying molecular mechanism remains poorly understood. Mating of haploid Saccharomyces cerevisiae cells of the opposite sex provides an ideal model system to study plasma membrane (PM) fusion in eukaryotic organisms. In this work, a multicolor flow cytometry assay based on ...

This PhD study focuses on developing an innovative in vitro test system using human-induced pluripotent stem cells (hiPSCs) to assess developmental toxicity. Traditional approaches rely on animal studies, which can be complex, costly, and less applicable to humans. The study introduces the UKK2 protocol combined with hiPSCs and transcriptomics to evaluate both developmental teratogenicity and cardiotoxicity. The research involves differentiating hiPSCs into various germ layers and cardiomyocy...

Leistungshalbleiter werden meist in schaltenden Anwendungen eingesetzt. Hartes Schalten ist hierfür ein gängiges und einfaches Funktionsprinzip, insbesondere bei induktiven Lasten. Hier können durch Verkürzung der Übergangsdauer zwischen Spannung und Strom die Schaltverluste reduziert werden. Die Nachteile schnellerer Übergänge in hart schaltenden Anwendungen sind in der Regel höhere Überschwingungen und außerdem die Erzeugung von elektromagnetischen Störungen. Die maximale Überspannung wird ...

Insbesondere Schulen in herausfordernden Lagen, die oftmals mit schulexternen und -internen Schwierigkeiten konfrontiert sind, sind auf eine ausgeprägte Schulentwicklungskapazität u. a. in Verbindung mit einem hohen Engagement und einer elaborierten Kooperation von Lehrkräften angewiesen, um die Belastungen bewältigen zu können. Bislang ist jedoch offen, welche Formen des Commitments und der Kooperation von Lehrkräften schulische Entwicklungsprozesse an Schulen in herausfordernden Lagen förde...

The search for the origin of charged cosmic rays remains one of the greatest challenges in astrophysics. Extremely accelerated particles propagate through the universe carrying the secrets of the most energetic cosmic phenomena. While neutral particles are not deflected by magnetic fields and point back to their sources, charged cosmic rays arrive on Earth as a diffuse flux, making it nearly impossible to identify their origin. The MAGIC telescopes, primarily designed to detect high-ener...