Eldorado - Repositorium der TU Dortmund

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Aktuellste Veröffentlichungen

Promoting structural sustainable design through the influence of quality control assessments
(2026-03-06) Lux, Til; Feiri, Tânia; Schulze-Ardey, Jan Philip; Hegger, Josef; Claßen, Martin; Ricker, Marcus
In structural reliability assessments, the selection of suitable parameters for the definition of stochastic models of component properties—such as concrete compressive strength, steel yield strength or geometric dimensions—is a prime requirement. Typically, during the production of structural components, several conformity control criteria, which are part of quality control assessments, are adopted to evaluate whether their properties comply with specified requirements. Previous investigations have demonstrated that the consideration of conformity control assessments in reliability studies might have a positive influence on the structural reliability of a component, thereby, enabling more material and resource efficient designs than conventional designs that do not take conformity control into account. In this investigation, a methodology grounded on the principles of reliability theory and Bayesian statistics is offered to quantify the positive effects of conformity control assessments in structural reliability levels. The practical application of this methodology is further demonstrated through an example extracted from previous investigations concerning the reliability level of a short concrete column subjected to compression. The results suggest that existing safety margins can be activated to adjust partial safety factors on the resistance side and, thus, optimise design solutions. Finally, possible improvements for the overall methodology are identified, opening avenues for the design of more sustainable structures.
Work in progress: use of wood‐based inserts in injection molding
(Wiley, 2026-03-20) Grundmann, David; Mainz, Michael; Munier, Leo; Dillenhöfer, Fabian; Pfriem, Alexander; Künne, Bernd; Bartz, Marcel
In the context of ever-shorter product development cycles and the necessary prototype development, the advantages of the injection molding process cannot be fully exploited because it is not possible to economically produce very small series. The aim of this study is to examine the suitability of soft tooling using wood-based mold inserts for small batch production in polymer injection molding. To this end, various types of wood are being tested in initial injection molding trials as part of this study, and their behavior under the process conditions is being compared. Those wooden molds are milled and tested in various injection molding tests. The produced parts as well as the used molds are then examined for wear, geometric accuracy and in terms of the tensile test specimen, for their load bearing capacity. It was shown that modified materials like laminated wood or compressed bamboo resist the loads of the injection molding process better than natural materials. Also, it was shown that the parts produced have a repeatable geometrical shape. After tool setup, it was possible to produce up to five consecutive workpieces of similar quality. Tensile tests showed reproducible strength values for ABS specimens while wood-fiber reinforced Polypropylene showed unpredictable behavior. Downsides of the new design approach are the longer cycle times which lead to material degradation and the fast wear of the wooden mold inserts.
The longitudinal relation between adolescents’ learning outcomes and internalizing symptoms: the role of ADHD symptoms
(Public Library of Science (PLoS), 2026-05-04) Visser, Linda; Ehm, Jan-Henning; Brandenburg, Janin; Chen, Mu-Hong
Objective The literature on bivariate relations between learning outcomes and symptoms of anxiety, depression, and ADHD is extensive. Much less research has been done into the trivariate longitudinal relations between learning outcomes, internalizing symptoms, and ADHD symptoms, which was the focus of the current study. Method The sample from the Adolescent Brain Cognitive Development (ABCD-) Study was largely representative for the US population in terms of, i.e., race and ethnicity and included 11,867 children aged 9 or 10 years (47.8% female; 52.2% male) at the start. Results The results of bi- and trivariate latent change score modelling with four timepoints showed that school records and symptoms of anxiety or depression were related, but school records did not predict these symptoms at the next timepoint, nor the other way around. ADHD was associated with both school records and symptoms of anxiety/ depression. Depression symptoms were a negative leading indicator of subsequent changes in ADHD. Conclusions The results suggest that ADHD symptoms do not form the main explanatory factor for the relation between school records and internalizing symptoms. They imply that it is important to recognize signs of depression at an early stage, so that such secondary problems can be prevented. Future research is needed to find underlying risk factors that can explain comorbidity, which can help identifying children with increased risk at an early stage.
Mammalian proteome profiling reveals readers and antireaders of strand‐symmetric and ‐asymmetric 5‐hydroxymethylcytosine‐modifications in DNA
(Wiley, 2026-01-04) Engelhard, Lena; Cakil, Zeyneb Vildan; Zambrano‐Mila, Marlon S.; Eppmann, Simone; Gonzalez, Tye; Linser, Rasmus; Janning, Petra; Becker, Sidney; Summerer, Daniel
The cytosine (C) modifications 5-methylcytosine (mC) and 5-hydroxymethylcytosine (hmC) are central regulatory elements of mammalian genomes. Both marks occur in double-stranded DNA in either strand-symmetric or -asymmetric fashion, but it is still poorly understood how this symmetry information is selectively read out by the nuclear proteome as the basis of potential symmetry-dependent regulation. We report enrichment/proteomics studies with promoter probes being strand-symmetrically or asymmetrically modified with C, mC, and hmC, enabling comparison of their reader profiles in the same sequence, tissue, and experimental contexts. We identify a high number of tissue-specific readers for hmC-modified sequences that fall into distinct, probe-specific sub-groups, including members of important transcription factor classes and chromatin regulators. Among them, we discover the master regulators MYC and MAX that play central roles in cell (de)differentiation and cancer progression to read hmC in a sequence-dependent manner. We also find RFX5, a transcription factor involved in primary MHC class II deficiency, to discriminate between hmC symmetries in CpG dyads. Our findings provide further support for the hypothesis that hmC symmetry information can provide distinct regulatory outputs and provide a resource for studying the molecular mechanisms triggered by symmetric and asymmetric hmC modifications in chromatin regulation during development and disease.
Grundlagen des inkrementellen Biegens im Gesenk
(2026) Holstein, Viktor; Tekkaya, A. Erman; Härtel, Sebastian
Der Einsatz von gebogenen Drähten, Rohren und Profilen findet einen breiten Anwendungsbereich in der Industrie. Betrachtet man den Trend, so stellt man fest, dass sich diese immer mehr Richtung flexibler und kundenorientierter Fertigung ändert. Dieses Umdenken hat einen erheblichen Einfluss auf die Wahl der Fertigungsverfahren. Statt werkzeuggebundener Verfahren kommen vermehrt Verfahren mit kinematischer Geometrieerzeugung zum Einsatz. Ein Grund für diese Entwicklung sind die geringen Werkzeugkosten der Verfahren, der Fortschritt bei der Berechnung der Geometrieerzeugung und die zunehmende Biegequalität der kinematischen Verfahren in den letzten Jahren. Das inkrementelle Biegen im Gesenk ist ein Biegeverfahren mit einer neuartigen Kinematik bei der Biegekonturerzeugung. Die Flexibilität und die Vorteile entsteht vorwiegend aus dem frei beweglichen Biegekopf und der flexiblen Gestaltung der Werkzeugform. Je nach Geometrie kann das Werkzeug angepasst und sogar wiederverwendet werden. Es lassen sich Biegeradien erreichen, die mit den bekannten kinematischen Verfahren nicht möglich sind und das bei einem vergleichbaren Werkzeugaufwand. In dieser Arbeit wird eine Basis für das grundlegende Verständnis dieses Verfahren geschaffen. Dazu werden der grundlegende Aufbau und Ablauf des Verfahrens und die Variation einiger Werkzeugelemente beschrieben. Es werden die Mechanismen des Prozesses betrachten, in Abhängigkeit von der Geometrie (1D / 2D / 3D). Analytische Ansätze werden vorgestellt, mit denen die benötigten Parameter für die Bahnplanung und die Antriebsachsen bestimmt werden können. Es wird auch ein analytischer Ansatz vorgestellt, der die Spannungsüberlagerung durch den Vorschub mitberücksichtigt. Anschließend wird die Bahnplanung für 2D und 3D Geometrien vorgestellt, inklusive des entwickelten Programms. Abschließend werden die Prozessgrenzen vorgestellt und die notwendigen Änderungen und Anpassungen für das Umformen von nicht kreisrunden Querschnitten.